Repositório Colecção: Capítulos de LivrosCapítulos de Livroshttps://hdl.handle.net/1822/37322024-03-29T15:32:06Z2024-03-29T15:32:06ZBiocomposites and bioceramics in tissue engineering: beyond the next decadePina, Sandra Cristina AlmeidaKown, Il KeunReis, R. L.Oliveira, Joaquim M.https://hdl.handle.net/1822/893942024-03-15T09:21:30ZTítulo: Biocomposites and bioceramics in tissue engineering: beyond the next decade
Autor: Pina, Sandra Cristina Almeida; Kown, Il Keun; Reis, R. L.; Oliveira, Joaquim M.
Resumo: Current strategies in the tissue engineering field are bringing functional biomaterials with required structural, mechanical, and biological performance able to endorse the repair and regeneration of injured or diseased tissues. Biocomposites formed by biodegradable polymers matrix and bioceramics have proved their effectiveness in clinics, namely in orthopaedics and dental medicine. They are being used as suture anchors and interference screws, while bioceramics are indicated as cements, blocks, granules, or as coatings for metal implants. The biocompatibility and osteoconductivity of the bioceramics together with the high mechanical properties provided by the polymers make them ideal candidates towards the designing of advanced scaffolds and implants. A comprehensive overview of recent research on bioceramics and related biocomposites for several TE purposes are herein presented. Bioceramics and biocomposites comprising bioinert, bioactive and bioresorbable ceramics, and natural and synthetic biodegradable polymers for scaffolds processing, and respective properties are demonstrated. Interest is given to advanced manufacturing as an emergent technology for complex personalized structures fabrication. Commercial bioceramics and biocomposites available for biomedical use are also summarized.
<b>Tipo</b>: bookPartTunable silk matrices using ionic liquids and their biomedical applicationsSilva, Simone S.Gomes, Joana M.Kundu, Subhas CReis, R. L.https://hdl.handle.net/1822/892292024-03-04T10:23:11ZTítulo: Tunable silk matrices using ionic liquids and their biomedical applications
Autor: Silva, Simone S.; Gomes, Joana M.; Kundu, Subhas C; Reis, R. L.
Resumo: Silk fibroin (SF) is a well-known natural protein with considerable potential to develop high-value materials for biomedical applications due to its intrinsic features, such as availability, versatility, and biocompatibility. In recent investigations, ionic liquids (ILs) have attracted attention as green solvents for tuning SF-based biomaterials. Like traditional solvents, ILs can be used as a solvent to process SF in different shapes, such as films, hydrogels, sponges, and microparticles. The resulting architectures can be applied to regenerate skin, bone, and cartilage and act as drug-delivery systems. Additionally, the IL platform has demonstrated its potential for creating SF-based therapeutic platforms with enhanced environmental and biological features. This chapter provides an up-to-date review of the SF-based matrices produced using ILs, the strategies used for processing, main properties, biomedical applications, and future perspectives.
<b>Tipo</b>: bookPartPreface [Hydrogels for tissue engineering and regenerative medicine: from fundamentals to applications]Silva-Correia, JoanaOliveira, Joaquim M.Reis, R. L.https://hdl.handle.net/1822/888032024-03-18T17:45:53Z2024-02-16T16:36:57ZTítulo: Preface [Hydrogels for tissue engineering and regenerative medicine: from fundamentals to applications]
Autor: Silva-Correia, Joana; Oliveira, Joaquim M.; Reis, R. L.
Resumo: Hydrogels are among the most important and used biomaterials for tissue engineering and regenerative medicine (TERM) strategies. This is mostly due to their similarities to the native extracellular matrix of tissues. Their hydration capacity and suitable porosity are crucial for the process of exchanging of nutrients/metabolites and gases that is required for maintaining functions and growth of normal cells. By means of functionalization, blending strategies, and playing with type of polymer (e.g., natural and synthetic) and polymerization method, properties of hydrogels may be tuned and enlarge their application for engineering different tissues and controlled delivery of drugs. Despite the remarkable process in hydrogel research, scientists still cannot fully address the growing demand for novel solutions based on hydrogels.
This book provides an overview on the recent advances catapulted by the successful application of hydrogels in TERM. It comprises three main sections that include contributions by leading experts in engineering, materials and life sciences, microbiology, and clinical medicine.
Section 1 discusses the fundamentals, open issues, and challenges involving the design, development, and sterilization of hydrogels. It also discusses other transversal topics such as intellectual property management and regulatory issues, which are critical for the successful translation of hydrogels into the market.
Section 2 overviews the latest and most important contributions from world experts on the processing of hydrogels. It presents the state-of-the-art methodologies for the synthesis and processing of functionalized and stimuli-responsive hydrogels.
Section 3 focuses on the relevant applications of hydrogels as injectable scaffolds and bioinks for TERM applications. Their biological activities and structural and physicochemical properties are discussed in depth, including the combination with emerging technologies.
<b>Tipo</b>: bookEditorial2024-02-16T16:36:57ZMarine-derived biomaterials for cancer treatmentOliveira, CatarinaCarvalho, Ana C.Reis, R. L.Neves, N. M.Martins, AlbinoSilva, Tiago H.https://hdl.handle.net/1822/887752024-02-15T09:06:33ZTítulo: Marine-derived biomaterials for cancer treatment
Autor: Oliveira, Catarina; Carvalho, Ana C.; Reis, R. L.; Neves, N. M.; Martins, Albino; Silva, Tiago H.
Editor: Kundu, Subhas C; Reis, R. L.
Resumo: Cancer treatments do not achieve the desired therapeutic effects so far, mainly due to unwanted side effects, specifically the toxicity to healthy tissues. The use of natural compounds, namely marine-derived biopolymers, may offer a promising alternative which will be the main focus of this book chapter. Since fucoidan and chitosan have been reported to present anticancer activity as single bioactive agents, their use will be further explored and described in relation to their mechanisms of action. In addition, the use of the abovementioned polysaccharides, along with alginate and carrageenan, have been mostly explored for the development of drug-delivery systems which will be further analyzed. In the last section of this chapter, the development of three-dimensional in vitro models will be discussed focusing on chitosan- and/or alginate-based systems.
<b>Tipo</b>: bookPartSulfated seaweed polysaccharidesInácio, Ana Rita MatosCarvalho, Ana C.Oliveira, CatarinaReys, Lara Priscila LopesSilva, Simone S.Neves, N. M.Martins, AlbinoReis, R. L.Silva, Tiago H.https://hdl.handle.net/1822/887742024-02-15T20:45:48ZTítulo: Sulfated seaweed polysaccharides
Autor: Inácio, Ana Rita Matos; Carvalho, Ana C.; Oliveira, Catarina; Reys, Lara Priscila Lopes; Silva, Simone S.; Neves, N. M.; Martins, Albino; Reis, R. L.; Silva, Tiago H.
Resumo: Mankind has used natural resources for many different applications, from food and clothes to drugs, but only recently is giving the due attention to the need for a responsible management of these resources toward sustainability. One of the approaches is to take the most out of its resources, addressing the several components of natural resources, which can be used in many industrial fields. In this regard, many natural compounds have been studied for the evaluation of biological activities with relevance for human health and well-being. Among the explored resources, the survey of marine organisms has been growing, particularly regarding microbiota and seaweeds or macroalgae. Macroalgae are macroscopic algae that are usually found on rocky shores, exhibiting a great diversity of colors, shapes and sizes. They are divided in three large groups, essentially based on their color: green macroalgae, brown macroalgae and red macroalgae. In recent decades, seaweeds have been widely used as a sustainable source of sulfated polysaccharides, which exhibiting diverse chemical and biological properties aim to address the demands of Tissue Engineering and Regenerative Medicine (TERM), as well as of other areas, such as cosmetics and food. This manuscript provides an overview of the paradigmatic examples of this type of biopolymer that can be obtained from the different groups of algae, detailing the chemical structure, general biological characteristics and most revealing properties.
<b>Tipo</b>: bookPart