Repositório Colecção: Comunicações/Communications (with refereeing)
https://hdl.handle.net/1822/1912
Comunicações/Communications (with refereeing)2024-03-28T18:36:55ZThe LiDAR hop-on-hop-off route: visiting the LiDARs past, present, and future landscapes
https://hdl.handle.net/1822/73436
Título: The LiDAR hop-on-hop-off route: visiting the LiDARs past, present, and future landscapes
Autor: Nunes-Pereira, E. J.; Peixoto, H.; Teixeira, J.; Simões, João Henrique Vivas Santos
Resumo: LiDAR technology is bounded with great expectations. This is a result of the high market prospects from several industries (notably the automotive) as well as LiDAR being a key enabling technology for automation. We will drive along the current two main avenues of LiDAR, targeted to autonomous driving. We will stop at minute technicalities of LiDAR implementations. However, occasionally we will also rise high, to get an eagle-eye view of the bigger picture. We discuss why there will not happen a one-single-expensive-LiDAR-fits-all-scenarios and why a several-cheap-complementary-LiDARs alternative is more rational. We discuss several aspects in which LiDAR changed our understanding of the landscape as well as the high impact it will have in society (economic and quality of life). Automotive LiDAR comes in an age where the societal focus is changing from private ownership to pay-as-you-use-services, and where personal responsibility will be gradually replaced by corporate liability. We will introduce some minor contributions from the Physics Centre of Minho and Porto Universities (mutual interference between commercial sensors; data processing in timing the back scattered LiDAR signal). And by the end of the route, we drop off the partaker to explore uncharted territory on its own.
<b>Tipo</b>: conferencePaperTranslucency, contrast ratio and fluorescence of esthetic materials
https://hdl.handle.net/1822/72959
Título: Translucency, contrast ratio and fluorescence of esthetic materials
Autor: Kauling, A. E. C.; Volpato, C. A. M; Carvalho, Óscar Samuel Novais; Pereira, Mário R.; Guth, J. F.
Resumo: This study evaluated the translucency, contrast ratio and fluorescence of resin nanoceramic and zirconia
materials employed for manufacturing of the indirect restorations.
<b>Tipo</b>: conferencePaperScanning electron microscopy analysis of sol-gel derived biocompatible glass
https://hdl.handle.net/1822/66183
Título: Scanning electron microscopy analysis of sol-gel derived biocompatible glass
Autor: Holmes-Smith, A. S.; Hungerford, Graham; Uttamlal, M.; Amaro, M.; Martins, P.; McBrearty, L.; Love, G.; Ferreira, Maria Isabel Pereira Lucas Calado
Resumo: Bioactive silica gels/polymer systems have been produced using a sol-gel route and their bio-compatibility has been investigated by immersing them in simulated body fluid (SBF). The porous monoliths have been characterised by SEM and EDX analysis where images obtained show pores on the surface of 10–200 μm. The silica gels are not homogeneous and distinct regions of silicon and calcium are observed. The growth of an apatite layer on the surface of the gels was evident after steeping in SBF.
<b>Tipo</b>: conferencePaper2020-07-29T17:01:00ZThe nanotherapy revolution: three different aplications of lipid nanosystems in therapeutics
https://hdl.handle.net/1822/53470
Título: The nanotherapy revolution: three different aplications of lipid nanosystems in therapeutics
Autor: Real Oliveira, M. Elisabete C.D.; Lúcio, M.; Soares, Telma; Fernandes, E.; Silva, J.
<b>Tipo</b>: conferencePosterAn innovative nanocarrier for neuroprotection
https://hdl.handle.net/1822/53469
Título: An innovative nanocarrier for neuroprotection
Autor: Real Oliveira, M. Elisabete C.D.; Lúcio, M.; Capela, J. P; Dias, Alberto Carlos Pires; Bastos, M.; Carvalho, F.; Soares, Telma
Resumo: In the last decades, the incidence of age-related neurodegenerative diseases (ARND) has gained relevance due to the progressive increase of average life expectancy and the limited therapeutic solutions available. The multifactorial etiology of ARND suggests the benefit of investing in the study of multi-target active compounds, such as polyphenols. Within polyphenols sources, the plants of Curcuma genus have acquired great importance mainly due to properties presented by Curcumin, a bioactive known for its anti-inflammatory and antioxidant properties recognised as valuable for the treatment/prophylaxis of ARND. However, in a first step of our research, by a multi-technique biophysical study, curcumin revealed a weak pharmacokinetic profile with low bioavailability and solubility, bioaccumulation, high affinity to human serum albumin as well as a tendency to induce membrane biophysical changes. Based on these results and to improve the benefits of curcumin in the treatment of ARND, this research aimed the encapsulation of curcumin in stealth nanocarriers (NC) of dioctadecyldimethyl-ammonium bromide (DODAB) and 1-oleoyl-rac-glycerol (MO) (1:2).
The NC present high encapsulation efficiency. Also, by dynamic/electrophoretic light scattering and nanoparticle tracking analysis, the NC developed exhibited sizes lower than 200 nm, high stability when stored up to 4 months and a positive superficial charge, allowing the permeation of the blood-brain barrier by absorption-mediated transcytosis which increases their interest for biomedical purposes.
An in vitro biphasic controlled release, of 94,5% of curcumin (R2=0,998) after 50 h was also observed. Furthermore, after successful PEGylation, the ability to prevent interactions with plasma proteins, was also confirmed. Moreover, by fluorescence decay of a lipophilic probe (DPH-PA) under the action of a peroxyl radical generator (AAPH) the antioxidant activity was confirmed. In undergoing assays, the effects of curcumin, empty NC and curcumin loaded NC are analysed in human dopaminergic SH-SY5Y cells using two cytotoxicity assays, dimethylthiazol diphenyltetrazolium (MTT) reduction and neutral red uptake (NR).
<b>Tipo</b>: oralPresentation