Repositório Colecção: Artigos em revistas científicas com arbitragem
https://hdl.handle.net/1822/3733
Artigos em revistas científicas com arbitragem2024-03-29T10:50:26ZSmart mitochondria-specific anchored gold-based nanosystem for integration of tumor imaging and treatment
https://hdl.handle.net/1822/90073
Título: Smart mitochondria-specific anchored gold-based nanosystem for integration of tumor imaging and treatment
Autor: Yin, Xuelian; Zhan, Lin; Ding, Lin; Chen, Xuerui; Zhang, Junfeng; Li, Chenchen; Zhang, Yuxi; Khan, Murad; Reis, R. L.; Wang, Yanli
Resumo: Although recent advances have been made in improving the efficacy of photodynamic therapy, efficient therapeutic approaches based on reactive oxygen species (ROS) are needed, particularly mitochondria-specific targeting of nanomaterials that can alter the internal environment of organelles. Herein, we report the facile synthesis of mitochondria-specific anchored nano-complexes (AG-CNP) comprised of a skeleton of gold and carbon atoms for cancer therapy. Compared to the effects of gold nanoclusters (Au NCs), AG-CNP shows enhanced fluorescence imaging effects, which can be used for tumor monitoring. AG-CNP targets the mitochondria and increases ROS damage in cancer cells. After treatment with AG-CNP, the tumor inhibition rate reaches 70.94%, which is 25.98% and 36.91% higher than that of free doxorubicin (DOX) and gemcitabine (Gem), respectively. Studying the mechanism of AG-CNP inhibiting cancer shows that AG-CNP can promote tumor cells to produce excessive ROS by overexpressing P53 and increasing the number of apoptotic cancer cells, which is caused by overexpression of Caspase1 that was closely related to cell apoptosis. AG-CNP is a promising anticancer drug that targets the mitochondria in vivo to trigger excessive ROS production in tumor cells and inhibit tumor growth.
<b>Tipo</b>: article2024-03-26T14:48:29ZZinc-organometallic framework vaccine controlled-release zn2+ regulates tumor extracellular matrix degradation potentiate efficacy of immunotherapy
https://hdl.handle.net/1822/90068
Título: Zinc-organometallic framework vaccine controlled-release zn2+ regulates tumor extracellular matrix degradation potentiate efficacy of immunotherapy
Autor: Ding, Lin; Liang, Minli; Li, Yuanyuan; Zeng, Mei; Liu, Meiting; Ma, Wei; Chen, Fuming; Li, Chenchen; Reis, R. L.; Li, Fu-Rong; Wang, Yanli
Resumo: Tumor extracellular matrix (ECM) not only forms a physical barrier for T cells infiltration, but also regulates multiple immunosuppressive pathways, which is an important reason for immunotherapy failure. The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) pathway plays a key role in activating CD8+ T cells, maintaining CD8+ T cells stemness and enhancing the antitumor effect. Herein, a zinc-organometallic framework vaccine (ZPM@OVA-CpG) prepared by self-assembly, which achieves site-directed release of Zn2+ in dendritic cell (DC) lysosomes and tumor microenvironment under acidic conditions, is reported. The vaccine actively targets DC, significantly enhances cGAS-STING signal, promotes DC maturation and antigen cross-presentation, and induces strong activation of CD8+ T cells. Meanwhile, the vaccine reaches the tumor site, releasing Zn2+, significantly up-regulates the activity of matrix metalloproteinase-2, degrades various collagen components of tumor ECM, effectively alleviates immune suppression, and significantly enhances the tumor infiltration and killing of CD8+ T cells. ZPM@OVA-CpG vaccine not only solves the problem of low antigen delivery efficiency and weak CD8+ T cells activation ability, but also achieves the degradation of tumor ECM via the vaccine for the first time, providing a promising therapeutic platform for the development of efficient novel tumor vaccines.
<b>Tipo</b>: article2024-03-26T14:06:26ZMulberry biomass-derived nanomedicines mitigate colitis through improved inflamed mucosa accumulation and intestinal microenvironment modulation
https://hdl.handle.net/1822/90065
Título: Mulberry biomass-derived nanomedicines mitigate colitis through improved inflamed mucosa accumulation and intestinal microenvironment modulation
Autor: Yang, Wenjing; Ma, Ya; Xu, Haiting; Zhu, Zhenhua; Wu, Jiaxue; Xu, Cheng; Sun, Wei; Zhao, Erhu; Wang, Min; Reis, R. L.; Kundu, Subhas C; Shi, Xiaoxiao; Xiao, Bo
Resumo: The therapeutic outcomes of conventional oral medications against ulcerative colitis (UC) are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory microenvironment. Herein, a fluorinated pluronic (FP127) was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles (MLNs) loading with resveratrol nanocrystals (RNs). The obtained FP127@RN-MLNs possessed exosome-like morphologies, desirable particle sizes (around 171.4 nm), and negatively charged surfaces (â 14.8 mV). The introduction of FP127 to RN-MLNs greatly improved their stability in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect. These MLNs could efficiently be internalized by colon epithelial cells and macrophages, reconstruct disrupted epithelial barriers, alleviate oxidative stress, provoke macrophage polarization to M2 phenotype, and down-regulate inflammatory responses. Importantly, in vivo studies based on chronic and acute UC mouse models demonstrated that oral administration of chitosan/alginate hydrogel-embedding FP127@RN-MLNs achieved substantially improved therapeutic efficacies compared with nonfluorinated MLNs and a first-line UC drug (dexamethasone), as evidenced by decreased colonic and systemic inflammation, integrated colonic tight junctions, and intestinal microbiota balance. This study brings new insights into the facile construction of a natural, versatile nanoplatform for oral treatment of UC without adverse effects.
<b>Tipo</b>: article2024-03-26T13:58:06ZAntibacterial smart hydrogels: new hope for infectious wound management
https://hdl.handle.net/1822/90048
Título: Antibacterial smart hydrogels: new hope for infectious wound management
Autor: Ahovan, Zahra Aliakbar; Esmaeili, Zahra; Eftekhari, Behnaz Sadat; Khosravimelal, Sadjad; Alehosseini, Morteza; Orive, Gorka; Dolatshahi-Pirouz, Alireza; Chauhan, Narendra Pal Singh; Janmey, Paul A.; Hashemi, Ali; Kundu, Subhas C; Gholipourmalekabadi, Mazaher
Resumo: Millions of people die annually due to uncured wound infections. Healthcare systems incur high costs to treat wound infections. Tt is predicted to become more challenging due to the rise of multidrug-resistant conditions. During the last decades, smart antibacterial hydrogels could attract attention as a promising solution, especially for skin wound infections. These antibacterial hydrogels are termed â smartâ due to their response to specific physical and chemical environmental stimuli. To deliver different drugs to particular sites in a controlled manner, various types of crosslinking strategies are used in the manufacturing process. Smart hydrogels are designed to provide antimicrobial agents to the infected sites or are built from polymers with inherent disinfectant properties. This paper aims to critically review recent pre-clinical and clinical advances in using smart hydrogels against skin wound infections and propose the next best thing for future trends. For this purpose, an introduction to skin wound healing and disease is presented and intelligent hydrogels responding to different stimuli are introduced. Finally, the most promising investigations are discussed in their related sections. These studies can pave the way for producing new biomaterials with clinical applications.
<b>Tipo</b>: article2024-03-26T11:47:57ZEvaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology
https://hdl.handle.net/1822/90035
Título: Evaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology
Autor: Milivojevic, Nevena; Carvalho, Mariana Rodrigues; Caballero, David; Radisavljevic, Snezana; Radoicic, Marija; Živanović, Marko; Kundu, Subhas C; Reis, R. L.; Filipović, Nenad; Oliveira, Joaquim M.
Resumo: Aim: Despite some successful examples of therapeutic nanoparticles reaching clinical stages, there is still a significant need for novel formulations in order to improve the selectivity and efficacy of cancer treatment. Methods: The authors developed two novel dendrimerâ gold (Au) complex-based nanoparticles using twodifferent synthesis routes: complexation method (formulation A) and precipitation method (formulation B). Using a biomimetic cancer-on-a-chip model, the authors evaluated the possible cytotoxicity and internalization by colorectal cancer cells of dendrimerâ Au complex-based nanoparticles. Results: The results showed promising capabilities of these nanoparticles for selectively targeting cancer cells and delivering drugs, particularly for the formulation A nanoparticles. Conclusion: This work highlights the potential of dendrimerâ Au complex-based nanoparticles as a new strategy to improve the targeting of anticancer drugs.
Descrição: To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/nnm-2023-0355
<b>Tipo</b>: article2024-03-26T11:05:26Z