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https://hdl.handle.net/1822/17364
Título: | GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression |
Autor(es): | Pinheiro, Céline Sousa, Bárbara Albergaria, André Paredes, Joana Dufloth, Rozany Vieira, Daniella Schmitt, Fernando C. Baltazar, Fátima |
Palavras-chave: | GLUT1 CAIX Monocarboxylate transporters (MCTs) CD147/EMMPRIN Breast carcinoma Immunohistochemistry |
Data: | Out-2011 |
Editora: | Consejería de Sanidad de la Comunidad Autónoma de Murcia Sociedad Española de Histología e Ingeniería Tisular; Histology and Histopathology |
Revista: | Histology and Histopathology |
Resumo(s): | The goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in breast cancer. The clinico-pathological value of GLUT1 and CAIX was also evaluated. For that, we analysed the immunohistochemical expression of GLUT1 and CAIX, in a large series of invasive breast carcinoma samples (n=124), previously characterized for MCT1, MCT4 and CD147 expression. GLUT1 expression was found in 46% of the cases (57/124), while CAIX was found in 18% of the cases (22/122). Importantly, both MCT1 and CD147, but not MCT4, were associated with GLUT1 and CAIX expression. Also, GLUT1 and CAIX correlated with each other. Concerning the clinico-pathological values, GLUT1 was associated with high grade tumours, basal-like subtype, absence of progesterone receptor, presence of vimentin and high proliferative index as measured by Ki-67. Additionally, CAIX was associated with large tumour size, high histological grade, basal-like subtype, absence of estrogen and progesterone receptors and presence of basal cytokeratins and vimentin expression. Finally, patients with CAIX positive tumours had a significantly shorter disease-free survival. The association between MCT1 and both GLUT1 and CAIX may result from hypoxia-mediated metabolic adaptations, which confer a glycolytic, acid-resistant and more aggressive phenotype to cancer cells. |
Tipo: | Artigo |
Descrição: | We thank Dr. Vitor Carneiro (pathologist from the Hospital do Divino Espírito Santo, Ponta Delgada, São Miguel, Azores), for his help in retrieving the breast cancer samples for this study. |
URI: | https://hdl.handle.net/1822/17364 |
ISSN: | 0213-3911 |
Versão da editora: | http://www.hh.um.es/2011/HH_26_10_2011.htm |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Pinheiro C_Histol Histopathol 2011.pdf | Documento principal | 1,27 MB | Adobe PDF | Ver/Abrir |