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https://hdl.handle.net/1822/18618
Título: | The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation |
Autor(es): | Carvalho, Agostinho Osório, Nuno S. Saraiva, Margarida Cunha, Cristina Almeida, A. J. Coelho, Maria Teixeira Ludovico, Paula Pedrosa, Jorge Pitzurra, Lucia Aversa, Franco Romani, Luigina Castro, António G. Rodrigues, Fernando José dos Santos |
Palavras-chave: | Allelic variants Toll-like receptors (TLRs) Human TLR9 promoter rs5743836 polymorphism IL-6-responding element B-cell proliferation TLR9 agonists TLR9 antagonists |
Data: | Nov-2011 |
Editora: | Public Library of Science |
Revista: | PLoS ONE |
Resumo(s): | In humans, allelic variants in Toll-like receptors (TLRs) associate with several pathologies. However, the underlying cellular and molecular mechanisms of this association remain largely unknown. Analysis of the human TLR9 promoter revealed that the C allele of the rs5743836 polymorphism generates several regulatory sites, including an IL-6-responding element. Here, we show that, in mononuclear cells carrying the TC genotype of rs5743836, IL-6 up-regulates TLR9 expression, leading to exacerbated cellular responses to CpG, including IL-6 production and B-cell proliferation. Our study uncovers a role for the rs5743836 polymorphism in B-cell biology with implications on TLR9-mediated diseases and on the therapeutic usage of TLR9 agonists/antagonists. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/18618 |
DOI: | 10.1371/journal.pone.0028256 |
ISSN: | 1932-6203 |
Versão da editora: | http://dx.doi.org/10.1371/journal.pone.0028256 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Carvalho A_PLoS One 2011.pdf | Documento principal | 378,08 kB | Adobe PDF | Ver/Abrir |