Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/19900

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dc.contributor.authorMorgado, Pedro-
dc.contributor.authorSilva, Miguel-
dc.contributor.authorSousa, Nuno-
dc.contributor.authorCerqueira, João José-
dc.date.accessioned2012-07-16T14:16:44Z-
dc.date.available2012-07-16T14:16:44Z-
dc.date.issued2012-06-
dc.identifier.issn1662-453Xpor
dc.identifier.urihttps://hdl.handle.net/1822/19900-
dc.description.abstractStress has a strong impact in the brain, impairing decision-making processes as a result of changes in circuits involving the prefrontal and orbitofrontal cortices and the striatum. Given that these same circuits are key for action control and outcome encoding, we hypothesized that adaptive responses to which these are essential functions, could also be targeted by stress. To test this hypothesis we herein assessed the impact of chronic stress in a Pavlovian-to-instrumental transfer (PIT) paradigm, a model of an adaptive response in which a previously conditioned cue biases an instrumental goal-directed action. Data reveals that rats submitted to chronic unpredictable stress did not display deficits in pavlovian conditioning nor on the learning of the instrumental task, but were impaired in PIT; importantly, after a stress-free period the PIT deficits were no longer observed. These results are relevant to understand how stress biases multiple incentive processes that contribute to instrumental performance.por
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT) - SFRH/SINTD/60129/2009, PTDC/SAU-NSC/111814/2009 FEDERpor
dc.description.sponsorshipFEDER - Operational program for competitivity factors – COMPETEpor
dc.language.isoengpor
dc.publisherFrontiers Mediapor
dc.relationinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/111814/PT-
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FSINTD%2F60129%2F2009/PT-
dc.rightsopenAccesspor
dc.subjectStresspor
dc.subjectConditioningpor
dc.subjectPavlovian-to-instrumental transferpor
dc.subjectChoicespor
dc.titleStress transiently affects Pavlovian-to-instrumental transferpor
dc.typearticlepor
dc.peerreviewedyespor
sdum.publicationstatuspublishedpor
oaire.citationStartPage1por
oaire.citationEndPage6por
oaire.citationIssue93por
oaire.citationTitleFrontiers in Neurosciencepor
oaire.citationVolume6por
dc.identifier.doi10.3389/fnins.2012.00093por
dc.subject.wosScience & Technologypor
sdum.journalFrontiers in Neurosciencepor
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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