Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/21961
Título: | Acridinyl methyl esters as photoactive precursors in the release of neurotransmitter amino acids |
Autor(es): | Piloto, Ana M. Hungerford, Graham Costa, Susana P. G. Gonçalves, M. Sameiro T. |
Palavras-chave: | Acridinyl methyl esters Photocleavable protecting groups Neurotransmitters Amino acids Caged compounds |
Data: | 2013 |
Editora: | Royal Society of Chemistry |
Revista: | Photochemical & Photobiological Sciences |
Citação: | Piloto AM, Hungerford G, Costa SP, Gonçalves MS. Acridinyl methyl esters as photoactive precursors in the release of neurotransmitter amino acids. Photochem Photobiol Sci. 2013 Feb;12(2):339-47. doi: 10.1039/c2pp25261a. |
Resumo(s): | An investigation of the use of an azaheterocycle, acridine, as an alternative photochemically removable protecting group for the carboxylic function of neurotransmitter amino acids was carried out. 9-Bromomethylacridine was used in the reaction with glycine, alanine, glutamic acid, β-alanine and γ-aminobutyric acid, to obtain model ester derivatives, which were irradiated at different wavelengths in a photochemical reactor. The process was followed by HPLC/UV, resulting in the release of the active molecule in short irradiation times. The results obtained using 419 nm irradiation show promise (35-98 min) for practical purposes. The compounds were further characterised via time-resolved fluorescence to elucidate their photophysical properties and determine the decay kinetics. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/21961 |
DOI: | 10.1039/c2pp25261a |
ISSN: | 1474-905X |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Final revised manuscript -AMP.pdf | Final draft post-refereeing | 536,87 kB | Adobe PDF | Ver/Abrir |