Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/22060

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dc.contributor.authorSalgueiro, D. A. L.-
dc.contributor.authorSousa, Cristina-
dc.contributor.authorFortes, A. Gil-
dc.contributor.authorAlves, M. José-
dc.date.accessioned2012-12-21T18:33:22Z-
dc.date.available2012-12-21T18:33:22Z-
dc.date.issued2012-
dc.identifier.issn1389-5575por
dc.identifier.urihttps://hdl.handle.net/1822/22060-
dc.description.abstractThis comprehensive review deals with the synthesis of 1-azafagomine, analogs, and derivatives having the Diels-Alder cycloaddition as the key step. Most of the compounds referred are racemic or have been resolved by lipase transesterification. There are two asymmetric cycloadditions leading to 1-azafagomine or to an analog. In one case both enantiomers of 1-azafagomine were prepared together with a pair of derivatives. The study comprises glycosidase inhibition studies of the target compounds to a set of glycosidic enzymes, and evidenced molecular features that enhance or diminish their activity as glycosidase inhibitors.por
dc.language.isoengpor
dc.publisherBentham Science Publisherspor
dc.rightsopenAccesspor
dc.subjectAzafagominepor
dc.subjectBiological activitypor
dc.subjectDiels-alder cycloadditionpor
dc.subjectGlycosidase inhibitorspor
dc.subjectMonocyclic analogspor
dc.subjectAzasugarspor
dc.titleDiels-alder cycloaddition in the synthesis of 1-azafagomine, analogs, and derivatives as glycosidase inhibitorspor
dc.typearticlepor
dc.peerreviewedyespor
sdum.publicationstatuspublishedpor
oaire.citationStartPage1465por
oaire.citationEndPage1476por
oaire.citationIssue14por
oaire.citationTitleMini Reviews in Medicinal Chemistrypor
oaire.citationVolume12por
dc.identifier.doi10.2174/138955712803832663por
dc.identifier.pmid22827178por
dc.subject.wosScience & Technologypor
sdum.journalMini Reviews in Medicinal Chemistrypor
Appears in Collections:CDQuim - Artigos (Papers)

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