Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/22312
Título: | Synthesis of novel 1-Aryl-3-[2-,3- Or 4-(Thieno[3,2-b]Pyridin-7-Ylthio)Phenyl]Ureas and evaluation as VEGFR2 Tyrosine kinase inhibitors |
Autor(es): | Peixoto, Daniela Queiroz, Maria João R. P. Abreu, Rui M. V. Froufe, Hugo J. C. Calhelha, Ricardo C. Ferreira, Isabel C. F. R. |
Data: | 2012 |
Editora: | Wiley-VCH Verlag |
Resumo(s): | Vascular endothelial growth factor receptor 2 (VEGFR2) tyrosine kinase is involved in cancer and in angiogenesis. Herein, we report the synthesis of novel1-aryl-3-[2-, 3- or 4-{thieno[3,2-b ]pyridin-7-ylthio) phenyl]ureas as VEGFR2 inhibitors by promoting the regioselective attack of the thiol group of the 4-aminothiophenol in the chlorine nucleophilic displacement on 7-chlorothieno[3,2-b]pyridine 1, obtaining the aminated compounds Za- c. These were reacted with arylisocyanates to give the corresponding 1,3-diarylureas 3a-c, 4a-c and Sa-c (see scheme). |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/22312 |
Versão da editora: | www.chem.med.chem.org |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Daniela.pdf | Documento principal | 756,35 kB | Adobe PDF | Ver/Abrir |