Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/22595
Título: | Protein microspheres as suitable devices for piroxicam release |
Autor(es): | Paulo, Artur Cavaco Silva, Raquel Ferreira, Helena Carvalho, Ana C. Gomes, Andreia C |
Palavras-chave: | Drug delivery systems Controlled release Piroxicam Protein microspheres Sonochemistry |
Data: | 2012 |
Editora: | Elsevier |
Revista: | Colloids and Surfaces B: Biointerfaces |
Resumo(s): | Bovine serum albumin-piroxicam (BSA-piroxicam) and human serum albumin-piroxicam (HSA-piroxicam) microspheres were sonochemically prepared and characterized. The use of polyvinyl alcohol (PVA) lead to an improvement of formulation characteristics, including smaller size, lower polydispersity index (PDl), higher entrapment efficiency and higher stability. The release kinetics of these proteinaceous microspheres was determined in presence of protease, indicating an anomalous drug transport mechanism (diffusion and polymer degradation). In presence of higher protease concentration, BSA microspheres exhibit Case II transport, leading to zero order release (protein degradation). These proteinaceous devices did not show cytotoxicity against human skin fibroblasts in vitro, for range concentrations below to 300 mg L−1, greatly supporting their potential application in the treatment of inflammatory diseases. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/22595 |
DOI: | 10.1016/j.colsurfb.2011.11.050 |
ISSN: | 0927-7765 |
Versão da editora: | http://dx.doi.org/10.1016/j.colsurfb.2011.11.050 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CBMA - Artigos/Papers DBio - Artigos/Papers DET/2C2T - Artigos em revistas internacionais com arbitragem científica |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
2012 Protein microspheres as suitable devices for piroxicam release.pdf | Protein microspheres as suitable devices for piroxicam release | 935,38 kB | Adobe PDF | Ver/Abrir |