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https://hdl.handle.net/1822/24093
Título: | Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis |
Autor(es): | Carvalho, Agostinho Giovannini, Gloria De Luca, Antonella D’Angelo, Carmen Casagrande, Andrea Iannitti, Rossana G. Ricci, Giovanni Cunha, Cristina Romani, Luigina |
Palavras-chave: | Dectin-1 Mucosal candidiasis Th1/Th17 II-22 genetic background Mucosal candidiasis, Th1/Th17, Il-22, genetic background |
Data: | Mai-2012 |
Editora: | Nature Publishing Group |
Revista: | Cellular and Molecular Immunology |
Resumo(s): | Recognition of β-glucans by dectin-1 has been shown to mediate cell activation, cytokine production and a variety of antifungal responses. Here, we report that the functional activity of dectin-1 in mucosal immunity to Candida albicans is influenced by the genetic background of the host. Dectin-1 was required for the proper control of gastrointestinal and vaginal candidiasis in C57BL/6 but not BALB/c mice, the latter actually showing increased resistance in the absence of dectin-1. Susceptibility of dectin-1-deficient C57BL/6 mice to infection was associated with defective IL-17A, aryl hydrocarbon receptor-dependent IL-22 production as well as adaptive Th1 responses. In contrast, resistance of dectin-1-deficient BALB/c mice was associated with increased IL-17A and IL-22 production, and the skewing towards Th1/Treg immune responses that provide immunological memory. Disparate canonical/noncanonical NF-κB signaling pathways downstream dectin-1were activated in the two different mouse strains. Thus, the net activity of dectin-1 in antifungal mucosal immunity is dependent on the host’s genetic background that affects both the innate cytokine production as well as the adaptive Th1/Th17 cell activation upon dectin-1 signaling. |
Tipo: | Artigo |
Descrição: | We thank Dr. Cristina Massi Benedetti for digital art and editing |
URI: | https://hdl.handle.net/1822/24093 |
DOI: | 10.1038/cmi.2012.1 |
ISSN: | 1672-7681 |
Versão da editora: | http://dx.doi.org/10.1038/cmi.2012.1 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Carvalho A_Cell Mol Immunol 2012 prep.pdf | Versão Preprint | 191,25 kB | Adobe PDF | Ver/Abrir |