Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/24342| Título: | In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein |
| Autor(es): | Martins, Margarida Isabel Barros Coelho Azóia, Nuno G. Ribeiro, Artur J. Shimanovich, Ulyana Silva, Carla Manuela Pereira Marinho da Paulo, Artur Cavaco |
| Palavras-chave: | Protein Surfactant Nanodispersion Transdermal perfusion Hydrophilic macromolecules |
| Data: | 2013 |
| Editora: | Elsevier Science BV |
| Revista: | Colloids and Surfaces B: Biointerfaces |
| Resumo(s): | Transdermal perfusion of a large protein is reported for the first time, using a nanoemulsion of bovine serum albumin (66 kDa) of 160 nm prepared by a solid-in-oil (S/O) process. Molecular dynamics simulations confirmed skin permeation by these formulations, with integration of the protein into the lipid bilayers. These results demonstrate the real possibility of delivering large proteins transdermally for a range of medical and cosmetic applications. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/24342 |
| DOI: | 10.1016/j.colsurfb.2013.02.032 |
| ISSN: | 0927-7765 |
| Versão da editora: | http://ac.els-cdn.com/S0927776513001616/1-s2.0-S0927776513001616-main.pdf?_tid=b4f90438-ce03-11e2-b26a-00000aacb35e&acdnat=1370452789_82fbaa692916dc26190e9496b22234ca |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| 1-s2.0-S0927776513001616-main.pdf | 2,24 MB | Adobe PDF | Ver/Abrir |
