Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/24881
Título: | Chitosan/bioactive glass nanoparticle composite membranes for periodontal regeneration |
Autor(es): | Mota, Joana Yu, Na Caridade, S. G. Luz, Gisela Gomes, Manuela E. Reis, R. L. Jansen, John A. Walboomers, X. Frank Mano, J. F. |
Palavras-chave: | Biomaterials Tissue engineering Guided tissue regeneration Chitosan Nanoparticles |
Data: | 2012 |
Editora: | Elsevier |
Revista: | Acta Biomaterialia |
Resumo(s): | Barrier membranes are used in periodontal applications with the aim of supporting periodontal regeneration by physically blocking migration of epithelial cells. The present work proposes a combination of chitosan (CHT) with bioactive glass nanoparticles (BG-NPs) in order to produce a novel guided tissue and bone regeneration membrane, fabricated by solvent casting. The CHT/BG-NP nanocomposite membranes are characterized in terms of water uptake, in mechanical tests, under simulated physiological conditions and in in vitro bioactivity tests. The addition of BG-NPs to CHT membranes decreased the mechanical potential of these membranes, but on the other hand the bioactivity improved. The membranes containing the BG-NPs induced the precipitation of bone-like apatite in simulated body fluid (SBF). Biological tests were carried out using human periodontal ligament cells and human bone marrow stromal cells. CHT/BG-NP composite membranes promoted cell metabolic activity and mineralization. The results indicate that the CHT/BG-NP composite membrane could potentially be used as a temporary guided tissue regeneration membrane in periodontal regeneration, with the possibility to induce bone regeneration. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/24881 |
DOI: | 10.1016/j.actbio.2012.06.040 |
ISSN: | 1742-7061 |
Versão da editora: | http://www.sciencedirect.com/science/article/pii/S1742706112002978 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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15887-Mota J et al.pdf | 1,23 MB | Adobe PDF | Ver/Abrir |