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https://hdl.handle.net/1822/24959| Título: | Physicochemical and biological evaluation of poly(ethylene glycol) methacrylate grafted onto poly(dimethyl siloxane) surfaces for prosthetic devices |
| Autor(es): | Gonçalves, S. Leirós, Ana Catarina Correia Van Kooten, Theo Dourado, Fernando Rodrigues, L. R. |
| Palavras-chave: | Poly(dimethyl siloxane) Surface-initiated atom transfer radical Polymerization Anti-adhesion Cytotoxicity Surface-initiated atom transfer radical polymerization |
| Data: | 2013 |
| Editora: | Elsevier Science BV |
| Revista: | Colloids and Surfaces B: Biointerfaces |
| Resumo(s): | Poly(dimethyl siloxane) (PDMS) was surface-polymerized with poly(ethylene glycol)methacrylate (PEGMA) by surface-initiated atom transfer radical polymerization (SI-ATRP) in aqueous media at room temperature. Modification of the PDMS surface followed a three-step procedure: (i) PDMS surface hydroxylation by UV/ozone exposure, immediately followed by (ii) covalent attachment of the initiator, 1-trichlorosilyl-2-(chloromethylphenyl)ethane, onto the hydroxylated PDMS, via chemical vapor deposition; finally (iii) PDMS surface-polymerization of PEGMA by ATRP. Modified PDMS was characterized by water contact angle measurement, SEM, FTIR-ATR, and XPS. Results showed that modified surfaces had a hydrophilic character, given the water contact angles around 60◦; FTIR-ATR and XPS analysis confirmed the presence of polymerized PEGMA on the surface of PDMS and the adhesion of Staphylococcus aureus GB 2/1 and Streptococcus salivarius GB 24/9 onto the modified surfaces was inhibited 94% and 81%, respectively. Finally, the modified PDMS showed no evidence of cytotoxic effects in in vitro assays using human skin fibroblasts. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/24959 |
| DOI: | 10.1016/j.colsurfb.2013.03.050 |
| ISSN: | 0927-7765 |
| e-ISSN: | 0927-7765 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
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