Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/26896
Título: | N1- and C6-substituted adenines : a regioselective and efficient synthesis |
Autor(es): | Senhorães, Nádia Costa, A. Luísa Silva, Deolinda Proença, M. Fernanda R. P. Dias, Alice |
Palavras-chave: | Adenine Imidazole Regioselective Carboxamidines Purine |
Data: | 26-Set-2013 |
Editora: | Elsevier |
Revista: | Tetrahedron |
Resumo(s): | New and efficient methods for the synthesis of N1-substituted and C6-substitued adenines were developed from the easily accessible 5-aminoimidazole-4-carboxamidines. Condensation of these compounds with triethyl orthoformate led to the selective synthesis of the N1-substituted adenines. Regioselective preparation of C6-substituted adenines could be accomplished when the same precursors were combined with dimethylformamide diethyl acetal. These C6-substituted adenines could also be obtained from the N1-substituted adenines by Dimroth rearrangement in the presence of dimethyl amine. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/26896 |
DOI: | 10.1016/j.tet.2013.09.063 |
ISSN: | 0040-4020 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
N1- and C6-substituted adenines- a regioselective and efficient synthesis_F.pdf Acesso restrito! | Documento principal | 356,61 kB | Adobe PDF | Ver/Abrir |