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TitleLipocalin-2 is involved in emotional behaviors and cognitive function
Author(s)Ferreira, Ana Catarina
Pinto, Vítor
Mesquita, Sandro
Novais, Ashley Cruz
Sousa, João Carlos
Neves, Margarida Correia
Sousa, Nuno
Palha, Joana Almeida
Marques, Fernanda
Issue date2013
PublisherFrontiers Media
JournalFrontiers in Cellular Neuroscience
Abstract(s)Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display anxious and depressive-like behaviors, as well as cognitive impairment in spatial learning tasks. These behavioral alterations were associated with a hyperactivation of the hypothalamic-pituitary-adrenal axis and with an altered brain cytoarchitecture in the hippocampus. More specifically, we found that the granular and pyramidal neurons of the ventral hippocampus, a region described to be associated with emotion, were hypertrophic, while neurons from the dorsal hippocampus, a region implicated in memory and cognition, were atrophic. In addition, LCN2-null mice presented synaptic impairment in hippocampal long-term potentiation. Whether the LCN2 effects are mediated through modulation of the level of corticosteroids or through a novel mechanism, the present observations bring further into light this immune-related protein as a player in the fine-tuning of behavior and of synaptic activity.
DescriptionLipocalin-2 is involved in emotional behaviors and cognitive function
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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