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https://hdl.handle.net/1822/27954
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Ferreira, Ana Catarina | - |
dc.contributor.author | Pinto, Vítor | - |
dc.contributor.author | Mesquita, Sandro | - |
dc.contributor.author | Novais, Ashley Cruz | - |
dc.contributor.author | Sousa, João Carlos | - |
dc.contributor.author | Neves, Margarida Correia | - |
dc.contributor.author | Sousa, Nuno | - |
dc.contributor.author | Palha, Joana Almeida | - |
dc.contributor.author | Marques, Fernanda | - |
dc.date.accessioned | 2014-02-13T16:11:46Z | - |
dc.date.available | 2014-02-13T16:11:46Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1662-5102 | por |
dc.identifier.uri | https://hdl.handle.net/1822/27954 | - |
dc.description | Lipocalin-2 is involved in emotional behaviors and cognitive function | por |
dc.description.abstract | Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display anxious and depressive-like behaviors, as well as cognitive impairment in spatial learning tasks. These behavioral alterations were associated with a hyperactivation of the hypothalamic-pituitary-adrenal axis and with an altered brain cytoarchitecture in the hippocampus. More specifically, we found that the granular and pyramidal neurons of the ventral hippocampus, a region described to be associated with emotion, were hypertrophic, while neurons from the dorsal hippocampus, a region implicated in memory and cognition, were atrophic. In addition, LCN2-null mice presented synaptic impairment in hippocampal long-term potentiation. Whether the LCN2 effects are mediated through modulation of the level of corticosteroids or through a novel mechanism, the present observations bring further into light this immune-related protein as a player in the fine-tuning of behavior and of synaptic activity. | por |
dc.description.sponsorship | We are grateful to Professor Shizuo Akira and Professor Cevayir Coban for the LCN2-null mice in the BALB/c background and to Professor Trude Flo for the LCN2-null mice in C57BL/6J background. Ana C. Ferreira, Sandro D. Mesquita, and Ashley Novais are recipients of Ph.D. and Fernanda Marques and Vitor Pinto are recipients of postdoctoral fellowships from Fundacao para a Ciencia e Tecnologia (Portugal). | por |
dc.language.iso | eng | por |
dc.publisher | Frontiers Media | por |
dc.rights | openAccess | por |
dc.subject | Lipocalin-2 | por |
dc.subject | Behavior | por |
dc.subject | Anxiety | por |
dc.subject | Depression | por |
dc.subject | Hippocampus | por |
dc.title | Lipocalin-2 is involved in emotional behaviors and cognitive function | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.frontiersin.org/ | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 10 | por |
oaire.citationIssue | JUL | por |
oaire.citationTitle | Frontiers in Cellular Neuroscience | por |
oaire.citationVolume | 7 | por |
dc.date.updated | 2014-02-13T11:30:36Z | - |
dc.identifier.doi | 10.3389/fncel.2013.00122 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Frontiers in Cellular Neuroscience | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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ferreira ac_front cells neurosc 2013.pdf | 977,92 kB | Adobe PDF | Ver/Abrir |