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TitleInterleukin-6 gene -174G>C and -636G>C promoter polymorphisms and prostate cancer risk
Author(s)Magalhães, J. F.
Cortinhas, A. J.
Albuquerque, C. M.
Baptista, C. S.
Ribeiro, R.
Viegas, Carlos A.
Matos, Augusto
Machado, João
Pires, Maria A.
Pinto, Henrique Guedes
Bessa, A. Martins
Leitão, J. C.
Bastos, E.
Prostate cancer
Issue date2013
JournalMolecular biology reports
Abstract(s)Prostate cancer (PCa) is one of the most commonly diagnosed internal malignancies affecting men. Due to the important roles of IL-6 in different physiological and pathophysiological processes,IL-6polymorphisms may modulate PCa risk.IL-6−174 G>C (rs 1800795, also designated −236 G>C) and −636 G>C (rs 1800796, also designated −572 G>C) promoter polymorphisms have been implicated in PCa susceptibility, albeit still controversial. A literature search using PubMed and Highwire databases was conducted, resulting in eight case–control studies concerning theIL-6−174 G>C polymorphism (11,613 PCa cases and 13,992 controls) and four case–control publications regarding theIL-6−636 G>C polymorphism (1,941 PCa cases and 3,357 controls). In order to derive a more precise estimation, a meta-analysis based upon these selected case–control studies was performed. There was no significant association betweenIL-6−174 G>C polymorphism and PCa increased risk. Nevertheless, the presence of allele C and the CC genotype were statistically significantly associated with decreased PCa risk in the overall analysis forIL-6−636 G>C polymorphism. Additional studies in larger samples and analyses of functional repercussions of these SNPs in prostate tumor cells are necessary to validate these findings.
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Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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