Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/29617
Título: | Cracking the Toll-like receptor code in fungal infections |
Autor(es): | Cunha, Cristina Romani, Luigina Carvalho, Agostinho |
Palavras-chave: | Fungal infections Genetic susceptibility Inflammation Innate immunity Toll-like receptors |
Data: | Out-2010 |
Editora: | Informa Healthcare |
Revista: | Expert Review of Anti-infective Therapy |
Resumo(s): | Innate control of fungal infection requires the specific recognition of invariant fungal molecular structures by a variety of innate immune receptors, including Toll-like receptors. In addition to the role in inducing protective immune responses, Toll-like receptor engagement may paradoxically favor fungal infections, by inducing inflammatory pathology and impairing antifungal immunity. Although the dissection of complex genetic traits modulating susceptibility to fungal infections is complex, the contribution of host genetics may hold the key to elucidating new risk factors for these severe, often fatal diseases. Understanding host-pathogen interactions at the innate immune interface will eventually lead to the development of new therapeutics and genetic markers in fungal infections. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/29617 |
DOI: | 10.1586/eri.10.93 |
ISSN: | 1478-7210 1744-8336 |
Versão da editora: | http://www.expert-reviews.com/doi/abs/10.1586/eri.10.93 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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cunha c_ expert rev anti infect ther 2010.pdf | 2,44 MB | Adobe PDF | Ver/Abrir |