Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/31691| Título: | Design of novel BSA/hyaluronic acid nanodispersions for transdermal pharma purposes |
| Autor(es): | Martins, Madalena A. Azóia, Nuno G. Shimanovich, Ulyana Matamá, Maria Teresa Gomes, Andreia C Silva, Carla Manuela Pereira Marinho da Paulo, Artur Cavaco |
| Palavras-chave: | Hyaluronic acid Bovine serum albumin Nanodispersion Transdermal transport Skin penetration |
| Data: | 2014 |
| Editora: | American Chemical Society |
| Revista: | Molecular Pharmaceutics |
| Citação: | Martins, Madalena; Azoia, Nuno G.; Shimanovich, U.; Matamá, Maria Teresa; Gomes, A. C.; Silva, Carla; Paulo, Artur Cavaco, Design of novel BSA/hyaluronic acid nanodispersions for transdermal pharma purposes. Molecular Pharmaceutics, 11(5), 1479-1488, 2014 |
| Resumo(s): | A novel transdermal hyaluronic acid (HA) conjugated with bovine serum albumin (BSA) was developed in the form of solid-in-oil (S/O) nanodispersion (129.7 nm mean diameter). Ex vivo skin penetration analysis by fluorescence and confocal observation of histological skin sections revealed the ability of BSA/HA nanodispersions to cross the stratum corneum and penetrate into the dermis. Furthermore, no significant toxicity was found in fibroblast and keratinocyte cells in vitro. These results proved the potential of the developed nanodispersion for transdermal delivery of hyaluronic acid constituting a high value to biopharmaceutical and cosmetics industries. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/31691 |
| DOI: | 10.1021/mp400657g |
| ISSN: | 1543-8392 |
| e-ISSN: | 1543-8384 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: | CBMA - Artigos/Papers DBio - Artigos/Papers |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| document_18071_1.pdf | 2,16 MB | Adobe PDF | Ver/Abrir |
