Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/31692

TitleSynthesis and antimicrobial activity of novel 5-aminoimidazole-4-carboxamidrazones
Author(s)Ribeiro, Ana Isabel F.
Gabriel, Carla
Cerqueira, Fátima
Maia, Marta
Pinto, Eugénia
Sousa, João Carlos
Medeiros, Rui
Proença, M. Fernanda R. P.
Dias, Alice
KeywordsImidazole
Amidrazone
Hydrazine
Antimicrobial
Antifungal
Issue date2014
PublisherElsevier
JournalBioorganic and Medicinal Chemistry Letters
Abstract(s)A mild and simple method was developed to prepare a series of fifteen 5-aminoimidazole 4-carboxamidrazones, starting from the easily accessible 5-amino-4-cyanoformimidoyl imidazoles. The antimicrobial activity of these novel amidrazones was screened against Gram positive (S. aureus) and Gram negative (E. coli, P. aeruginosa) bacteria and Candida sp. (C. albicans, C. krusei, C. parapsilosis). Only a subset of compounds displayed fair-moderate activity against S. aureus and E. coli but all exhibited activity against Candida sp. The three most potent antifungal compounds were further tested against C. neoformans, A. fumigatus and three dermatophytes (T. rubrum, T. mentagrophytes, M. gypseum). These three hit compounds strongly inhibited C. krusei and C. neoformans growth, although their activity on filamentous fungi was very weak when compared to the activity on yeasts.
TypeArticle
URIhttps://hdl.handle.net/1822/31692
DOI10.1016/j.bmcl.2014.08.025
ISSN0960-894X
Publisher versionhttp://dx.doi.org/10.1016/j.bmcl.2014.08.025
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CDQuim - Artigos (Papers)

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