Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/31692
Título: | Synthesis and antimicrobial activity of novel 5-aminoimidazole-4-carboxamidrazones |
Autor(es): | Ribeiro, Ana Isabel F. Gabriel, Carla Cerqueira, Fátima Maia, Marta Pinto, Eugénia Sousa, João Carlos Medeiros, Rui Proença, M. Fernanda R. P. Dias, Alice |
Palavras-chave: | Imidazole Amidrazone Hydrazine Antimicrobial Antifungal |
Data: | 2014 |
Editora: | Elsevier |
Revista: | Bioorganic and Medicinal Chemistry Letters |
Resumo(s): | A mild and simple method was developed to prepare a series of fifteen 5-aminoimidazole 4-carboxamidrazones, starting from the easily accessible 5-amino-4-cyanoformimidoyl imidazoles. The antimicrobial activity of these novel amidrazones was screened against Gram positive (S. aureus) and Gram negative (E. coli, P. aeruginosa) bacteria and Candida sp. (C. albicans, C. krusei, C. parapsilosis). Only a subset of compounds displayed fair-moderate activity against S. aureus and E. coli but all exhibited activity against Candida sp. The three most potent antifungal compounds were further tested against C. neoformans, A. fumigatus and three dermatophytes (T. rubrum, T. mentagrophytes, M. gypseum). These three hit compounds strongly inhibited C. krusei and C. neoformans growth, although their activity on filamentous fungi was very weak when compared to the activity on yeasts. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/31692 |
DOI: | 10.1016/j.bmcl.2014.08.025 |
ISSN: | 0960-894X |
Versão da editora: | http://dx.doi.org/10.1016/j.bmcl.2014.08.025 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Synthesis Antimicrobial Activity of Novel Amidrazones.pdf Acesso restrito! | Dados recolhidos | 260,22 kB | Adobe PDF | Ver/Abrir |