Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/33445
Título: | Pathogenicity phenomena in three model systems: from network mining to emerging system-level properties |
Autor(es): | Santos, Nadine Correia Pereira, Maria Olívia Lourenço, Anália |
Palavras-chave: | Pathogenicity Biofilm-associated infections Drug therapeutics Network reconstruction In silico tools |
Data: | 2015 |
Editora: | Oxford University Press |
Revista: | Briefings in Bioinformatics |
Resumo(s): | Understanding the interconnections of microbial pathogenicity phenomena, such as biofilm formation, quorum sensing and antimicrobial resistance, is a tremendous open challenge for biomedical research. Progress made by wet-lab researchers and bioinformaticians in understanding the underlying regulatory phenomena has been significant, with converging evidence from multiple high-throughput technologies. Notably, network reconstructions are already of considerable size and quality, tackling both intracellular regulation and signal mediation in microbial infection. Therefore, it stands to reason that in silico investigations would play a more active part in this research. Drug target identification and drug repurposing could take much advantage of the ability to simulate pathogen regulatory systems, hostpathogen interactions and pathogen cross-talking. Here, we review the bioinformatics resources and tools available for the study of the gram-negative bacterium Pseudomonas aeruginosa, the gram-positive bacterium Staphylococcus aureus and the fungal species Candida albicans. The choice of these three microorganisms fits the rationale of the review converging into pathogens of great clinical importance, which thrive in biofilm consortia and manifest growing antimicrobial resistance. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/33445 |
DOI: | 10.1093/bib/bbt071 |
ISSN: | 1477-4054 |
e-ISSN: | 1467-5463 |
Versão da editora: | http://bib.oxfordjournals.org/ |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_15354_1.pdf Acesso restrito! | 567,91 kB | Adobe PDF | Ver/Abrir |