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https://hdl.handle.net/1822/35305| Title: | Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors |
| Author(s): | Loureiro, Ana Isabel Sá Bernardes, Gonçalo J. L. Shimanovich, Ulyana Sárria, M. P. Nogueira, Eugénia Preto, Ana Gomes, Andreia Paulo, Artur Cavaco |
| Keywords: | protein nanoemulsions folic acid CORM-2 specific uptake targeted drug delivery |
| Issue date: | Jul-2015 |
| Publisher: | Elsevier B.V. |
| Journal: | Nanomedicine: Nanotechnology, Biology, and Medicine |
| Citation: | Loureiro, Ana; Bernardes, Gonçalo J. L.; Shimanovich, Ulyana; Sárria, M. P.; Nogueira, Eugénia; Preto, Ana; Gomes, Andreia C.; Paulo, Artur Cavaco, Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors. Nanomedicine: Nanotechnology, Biology, and Medicine, 11(5), 1077-1083, 2015 |
| Abstract(s): | Folic Acid (FA)-tagged protein nanoemulsions were found to be preferentially internalized on B-cell lymphoma cell line (A20 cell line), which, for the first time, are reported to express folate receptor (FR)-alpha. Carbon monoxide releasing molecule-2 (CORM-2) was incorporated in the oil phase of the initial formulation. FA-functionalized nanoemulsions loaded with CORM-2 exhibited a considerable antitumor effect and an increased survival of BALB/c mice bearing subcutaneous A20 lymphoma tumors. The developed nanoemulsions also demonstrated to be well tolerated by these immunocompetent mice. Thus, the results obtained in this study demonstrate that FA-tagged protein nanoemulsions can be successfully used in cancer therapy, with the important ability to delivery drugs intracellularly. |
| Type: | Article |
| URI: | https://hdl.handle.net/1822/35305 |
| DOI: | 10.1016/j.nano.2015.02.022 |
| ISSN: | 1549-9634 |
| e-ISSN: | 1549-9642 |
| Publisher version: | http://www.sciencedirect.com/science/article/pii/S1549963415000726 |
| Peer-Reviewed: | yes |
| Access: | Open access |
| Appears in Collections: | DBio - Artigos/Papers |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| document_19878_1.pdf | 683,83 kB | Adobe PDF | View/Open |
