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|Title:||Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors|
|Author(s):||Loureiro, Ana Isabel Sá|
Bernardes, Gonçalo J. L.
Sárria, M. P.
Paulo, Artur Cavaco
targeted drug delivery
|Journal:||Nanomedicine: Nanotechnology, Biology, and Medicine|
|Citation:||Loureiro, Ana; Bernardes, Gonçalo J. L.; Shimanovich, Ulyana; Sárria, M. P.; Nogueira, Eugénia; Preto, Ana; Gomes, Andreia C.; Paulo, Artur Cavaco, Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors. Nanomedicine: Nanotechnology, Biology, and Medicine, 11(5), 1077-1083, 2015|
|Abstract(s):||Folic Acid (FA)-tagged protein nanoemulsions were found to be preferentially internalized on B-cell lymphoma cell line (A20 cell line), which, for the first time, are reported to express folate receptor (FR)-alpha. Carbon monoxide releasing molecule-2 (CORM-2) was incorporated in the oil phase of the initial formulation. FA-functionalized nanoemulsions loaded with CORM-2 exhibited a considerable antitumor effect and an increased survival of BALB/c mice bearing subcutaneous A20 lymphoma tumors. The developed nanoemulsions also demonstrated to be well tolerated by these immunocompetent mice. Thus, the results obtained in this study demonstrate that FA-tagged protein nanoemulsions can be successfully used in cancer therapy, with the important ability to delivery drugs intracellularly.|
|Appears in Collections:||CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series|
DBio - Artigos/Papers