Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/38484
Título: | Tendon regeneration through a scaffold-free approach: development of tenogenic magnetic hASCs sheets |
Autor(es): | Gonçalves, A. I. Rodrigues, M. T. Reis, R. L. Gomes, Manuela E. |
Palavras-chave: | hASCs Scaffold-free Tendon |
Data: | Ago-2015 |
Editora: | Mary Ann Liebert |
Citação: | Gonçalves A. I., Rodrigues M. T., Reis R. L., Gomes M. E. Tendon Regeneration Through a Scaffold-free Approach: Development of Tenogenic Magnetic hASCs Sheets, TISSUE ENGINEERING: Part A, Vol. 21, Issue S1, pp. S-357, doi:10.1089/ten.tea.2015.5000.abstracts, 2015 |
Resumo(s): | Tendon's regeneration is limited, demanding for cell-based strategies to fully restore their functionality upon injury. The concept of magnetic force-based TE(1), generally using magnetic nanoparticles may enable, for example, stem cell stimulation and/or remote control over TE constructs. Thus, we originally propose the development of magnetic cell sheets (magCSs) with tenogenic capability, aimed at promoting tendon's regeneration. A Tenomodulin (TNMD+) subpopulation was sorted from human adipose stem cells (hASCs), using TNMD-coated immunomagnetic beads(2) and used as cell source for the development of magCSs. Briefly, cells were labeled with iron oxide composite particles (Micromod) and cultured for 7 days in α-MEM medium with or without magnetic stimulation provided by a magnetic device (nanoTherics). CSs were retrieved from the plates using magnet attraction as contiguous sheets of cells within its own deposited ECM. |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/38484 |
Versão da editora: | http://online.liebertpub.com/doi/abs/10.1089/ten.tea.2015.5000.abstracts |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
18502-abstract.pdf | 31,93 kB | Adobe PDF | Ver/Abrir |