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TitleAntifungal action of three (Z)-5-amino-N'-aryl-1-methyl-1H-imidazole-4-carbohydrazonamides
Author(s)Maia, M.
Gabriel, C.
Cravo, S.
Dias, Alice
Ribeiro, A.
Proença, M. Fernanda R. P.
Cerqueira, F.
Pinto, E.
KeywordsQuímica Orgânica
Química Terapêutica
Issue date1-Dec-2015
Abstract(s)[Excerpt] The incidence of fungal infections has greatly increased in patients under sustained immunosuppression with considerable risk associated. Difficulties regarding prompt diagnosis and the limited therapeutic options dictate high mortality rates. Available antifungals display substantial toxicity, a predictable consequence of the cellular structure of the organisms involved, reduced spectrum of activity, and drug interactions. Our group had previously identified three (Z)-5-amino-N'-aryl-1-methyl-1H-imidazole-4-carbohydrazonamides 1 [aryl= phenyl (1a), 4-fluorophenyl (1b), 3fluorophenyl (1c)] as potent antifungal agents.1 (...)
AccessRestricted access (UMinho)
Appears in Collections:CDQuim - Comunicações e Proceedings

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