Please use this identifier to cite or link to this item:

TitleGoblet cell density association with tear function and ocular surface physiology
Author(s)Sapkota, Kishor
Franco, Sandra
Sampaio, Paula
Lira, Madalena
KeywordsGoblet cell density
Schirmer score
Tear break-up time
Bulbar redness
Corneal staining
Issue dateAug-2015
JournalContact Lens and Anterior Eye
CitationSapkota, K., Franco, S., Sampaio, P., & Lira, M. (2015). Goblet cell density association with tear function and ocular surface physiology. Contact Lens & Anterior Eye, 38(4), 240-244. doi: 10.1016/j.clae.2015.01.016
Abstract(s)Purpose: To determine the relationship of goblet cell density (GCD) with tear function and ocular surface physiology. Methods: This was a cross-sectional study conducted in 35 asymptomatic subjects with mean age 23.8±3.6 years. Tear film assessment, conjunctiva and cornea examination were done in each subject. Conjunctival impression cytology was performed by applying Nitrocellulose Millipore MFTM-Membrane filter over the superior bulbar conjunctiva. The filter paper was than fixed with 96% ethanol and stained with Periodic Acid Schiff, Hematoxylin and Eosin. GCD was determined by optical microscopy. Relation between GCD and Schirmer score, tear break-up time (TBUT), bulbar redness, limbal redness and corneal staining was determined. Results: The mean GCD was 151±122 cells/mm2. GCD was found higher in eyes with higher Schirmer score but it was not significant (p = 0.75). There was a significant relationship ofGCDwith TBUT (p = 0.042). GCD was not correlated with bulbar redness (p = 0.126), and limbal redness (p = 0.054) as well as corneal staining (p = 0.079). No relationship of GCD with age and gender of the subjects (p > 0.05) was observed. Conclusion: GCD was found correlated with TBUT but no significant correlation was found with the aqueous portion of the tear, limbal as well as bulbar redness and corneal staining.
AccessRestricted access (UMinho)
Appears in Collections:CDF - OCV - Artigos/Papers (with refereeing)

Files in This Item:
File Description SizeFormat 
Goblet cell density.pdf
  Restricted access
1,07 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID