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https://hdl.handle.net/1822/40476
Título: | Biosurfactants produced by marine microorganisms with therapeutic applications |
Autor(es): | Gudiña, Eduardo J. Teixeira, J. A. Rodrigues, L. R. |
Palavras-chave: | Biosurfactant Antimicrobial activity Anti-adhesive activity Anti-biofilm activity Anti-cancer activity Metagenomics Cancer activity |
Data: | Fev-2016 |
Editora: | MDPI |
Revista: | Marine Drugs |
Citação: | Gudiña, Eduardo J.; Teixeira, J. A.; Rodrigues, L. R., Biosurfactants produced by marine microorganisms with therapeutic applications. Marine Drugs, 14(38), 1-15, 2016 |
Resumo(s): | Marine microorganisms possess unique metabolic and physiological features and are an important source of new biomolecules, such as biosurfactants. Some of these surface-active compounds synthesized by marine microorganisms exhibit antimicrobial, anti-adhesive and anti-biofilm activity against a broad spectrum of human pathogens (including multi-drug resistant pathogens), and could be used instead of the existing drugs to treat infections caused by them. In other cases, these biosurfactants show anti-cancer activity, which could be envisaged as an alternative to conventional therapies. However, marine biosurfactants have not been widely explored, mainly due to the difficulties associated with the isolation and growth of their producing microorganisms. Culture-independent techniques (metagenomics) constitute a promising approach to study the genetic resources of otherwise inaccessible marine microorganisms without the requirement of culturing them, and can contribute to discover novel biosurfactants with significant biological activities. This paper reviews the most relevant biosurfactants produced by marine microorganisms with potential therapeutic applications and discusses future perspectives and opportunities to discover novel molecules from marine environments. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/40476 |
DOI: | 10.3390/md14020038 |
ISSN: | 1660-3397 |
e-ISSN: | 1660-3397 |
Versão da editora: | http://www.mdpi.com/1660-3397/14/2/38 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_37806_1.pdf | 478,9 kB | Adobe PDF | Ver/Abrir |