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https://hdl.handle.net/1822/40617
Título: | Improved burn wound healing using a bioactive peptide |
Autor(es): | Gama, F. M. Silva, João P. |
Palavras-chave: | Wound healing carbopol AMP |
Data: | 19-Nov-2015 |
Citação: | Gama, F. M.; Silva, João P., Improved burn wound healing using a bioactive peptide. BEC2015 - 7th International Bioengineering Congress. Izmir, Turkey, Nov. 19-21, 36-36, 2015. ISBN: 978-605-66028-0-1 |
Resumo(s): | [Excerpt] Antimicrobial peptides (AMPs) are good candidates to treat burn wounds, a major cause of morbidity, impaired life quality and resources consumption in developed countries. We took advantage of a commercially available hydrogel, Carbopol, a vehicle for topical administration that maintains a moist environment within the wound site. We hypothesized that the incorporation of LLKKK18 conjugated to dextrin would improve the healing process in rat burns. Whereas the hydrogel improves healing, LLKKK18 released from the dextrin conjugates further accelerates wound closure, and simultaneously improving the quality of healing. Indeed, the release of LLKKK18 reduces oxidative stress and inflammation (low neutrophil and macrophage infiltration and pro-inflammatory cytokines levels). Importantly, it induced a faster resolution of the inflammatory stage through early M2 macrophage recruitment. In addition, LLKKK18 stimulates angiogenesis (increased VEGF and microvessel development in vivo), potentially contributing to more effective transport of nutrients and cytokines. Moreover, collagen staining evaluated by Masson’s Trichrome was visually much more intense after treatment with LLKKK18, suggesting higher collagen deposition. (...) |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/40617 |
ISBN: | 978-605-66028-0-1 |
Versão da editora: | http://bec2015.org/wp-content/uploads/2016/02/Book-of-Abstract-SON.pdf |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_37820_1.pdf | 139,75 kB | Adobe PDF | Ver/Abrir |