Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/41040
Título: | The positive effect on ketamine as a priming adjuvant in antidepressant treatment. |
Autor(es): | Almeida, António Manuel Melo Soares Kokras, N. Dalla, C. Ferreira, Ana Catarina Silva, Ana Paula Ventura Sousa, Nuno Pêgo, José M. |
Data: | Mai-2015 |
Editora: | Nature Publishing Group |
Revista: | Translational Psychiatry |
Citação: | Melo, A., Kokras, N., Dalla, C., Ferreira, C., Ventura-Silva, A. P., Sousa, N., & Pêgo, J. M. (2015). The positive effect on ketamine as a priming adjuvant in antidepressant treatment. Translational psychiatry, 5(5) |
Resumo(s): | Ketamine is an anesthetic with antidepressant properties. The rapid and lasting effect of ketamine observed in preclinical and clinical research makes it a promising therapeutic to improve current major depression (MD) treatment. Our work intended to evaluate whether the combined use of classic antidepressants (imipramine or fluoxetine) and ketamine would improve the antidepressant response. Using an animal model of depressive-like behavior, we show that the addition of ketamine to antidepressants anticipates the behavioral response and accelerates the neuroplastic events when compared with the use of antidepressants alone. In conclusion, our results suggest the need for a reappraisal of the current pharmacological treatment of MD. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/41040 |
DOI: | 10.1038/tp.2015.66 |
ISSN: | 2158-3188 |
Versão da editora: | http://www.nature.com/tp/journal/v5/n5/abs/tp201566a.html |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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melo et al - tranls psych.pdf | 4,37 MB | Adobe PDF | Ver/Abrir |