Synthesis of 1-(4-bromophenyl)-1H-pyrrole by Clauson-Kass reaction

Abstract

The aim of this work is the synthesis of 1-(4-bromophenyl)-1H-pyrrole via the Clausson-Kass reaction, using simple experimental techniques and commercially available reagents. Several experimental techniques will be implemented including heating at reflux, liquid-liquid extraction, gravity and vacuum filtration, thin layer chromatography (TLC), and melting point determination. The determination of the structure of the compound synthesized will be also performed using 1H NMR spectroscopy techniques. The duration of the experiment is 2 sessions: session 1: preparation of 1-(4-bromophenyl)-1H-pyrrole; session 2: purification of 1-(4-bromophenyl)-1H-pyrrole. The difficulty level of this experiment is low and the level of study is medium.