Deciphering the role of Staphylococcus aureus in Pseudomonas aeruginosa adaptation to cystic fibrosis lungs: bystander or intervener?

Abstract

Background: Pseudomonas aeruginosa is the major responsible for the high mortality rate of cystic fibrosis (CF) patients due to the development of chronic infections. To long persist, P. aeruginosa uses sophisticated mechanisms to achieve fulladaptation, mainly triggered by the harsh environmental conditions of CF lungs. The influence of Staphylococcus aureus, a primary colonizer of CF lungs, in increasing P. aeruginosa pathogenicity has also been reported. The main objective of this study was to decipher the impact of S. aureus on P. aeruginosa pathogenicity using in vitro conditions mimicking CF lungs. [...]