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TitleValue of pH regulators in the diagnosis, prognosis and treatment of cancer
Author(s)Granja, Sara Costa
Tavares-Valente, Diana
Queirós, Odília
Baltazar, Fátima
KeywordsMonocarboxylate transporters
Carbonic anhydrases
Sodium-hydrogen exchangers
pH regulators
Sodium-hydrogen exchangers pH regulators
Issue date6-Apr-2017
JournalSeminars in Cancer Biology
CitationGranja, S., Tavares-Valente, D., Queirós, O., & Baltazar, F. (2017, January). Value of pH regulators in the diagnosis, prognosis and treatment of cancer. In Seminars in cancer biology. Academic Press
Abstract(s)Altered metabolism, associated with acidification of the extracellular milieu, is one of the major features of cancer. As pH regulation is crucial for the maintenance of all biological functions, cancer cells rely on the activity of lactate exporters and proton transporters to regulate their intracellular pH. The major players in cancer pH regulation are proton pump ATPases, sodium-proton exchangers (NHEs), monocarboxylate transporters (MCTs), carbonic anhydrases (CAs) and anion exchangers (AEs), which have been shown to be upregulated in several human malignancies. Thanks to the activity of the proton pumps and transporters, tumours acidify their microenvironment, becoming more aggressive and resistant to therapy. Thus, targeting tumour pH may contribute to more effective anticancer strategies for controlling tumour progression and therapeutic resistance. In the present study, we review the role of the main pH regulators expressed in human cancer cells, including their diagnostic and prognostic value, as well as their usefulness as therapeutic targets.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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