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TitleSystemic interleukin-4 administration after spinal cord injury modulates inflammation and promotes neuroprotection
Author(s)Lima, Rui Augusto Ribeiro
Monteiro, Susana Isabel Gonçalves
Lopes, José Luís Pimenta
Barradas, Pedro
Vasconcelos, Natália L.
Gomes, Eduardo Domingos Correia
Silva, Rita Catarina Assunção Ribeiro
Teixeira, Fábio Gabriel Rodrigues
Morais, Mónica
Sousa, Nuno
Salgado, A. J.
Silva, Nuno André Martins
KeywordsSpinal cord injury
Issue date24-Oct-2017
PublisherMDPI Publishing
CitationLima, R., Monteiro, S., Lopes, J. P., et. al. (2017). Systemic Interleukin-4 Administration after Spinal Cord Injury Modulates Inflammation and Promotes Neuroprotection. Pharmaceuticals, 10(4), 83
Abstract(s)Traumatic spinal cord injury (SCI) causes dramatic disability and dysfunction in the motor, sensory and autonomic systems. The severe inflammatory reaction that occurs after SCI is strongly associated with further tissue damage. As such, immunomodulatory strategies have been developed, aimed at reducing inflammation, but also at shaping the immune response in order to protect, repair and promote regeneration of spared neural tissue. One of those promising strategies is the intraspinal administration of the cytokine interleukin-4 (IL-4) that was shown to promote a phenotype on specific immune cells associated with neuroprotection and repair. In this work, we evaluated if a systemic delivery of IL-4 for a 7-days period was also capable of promoting neuroprotection after SCI by analyzing different neural cells populations and motor recovery. IL-4 treatment promoted an elevation of the anti-inflammatory cytokine IL-10 in the serum both at 24 h and 7 days after injury. Locally, treatment with IL-4 led to a reduction on cells expressing markers associated with inflammation, CD11b/c and iNOS. Importantly, IL-4 treatment increased the neuronal markers beta III-tubulin and NeuN, and the oligodendrocyte marker O4, suggesting a neuroprotective effect. Moreover, 100% of the animals treated with IL-4 were able to recover weight support against only 33% of saline treated animals. Overall, these results show that systemic administration of IL-4 positively impacts different aspects of spinal cord injury, creating a more favorable environment for recovery to take place.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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