Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/50323
Título: | Biophysical characterization, nanoscale composition and cell uptake studies of pH-sensitive drug delivery systems |
Autor(es): | Real Oliveira, M. Elisabete C.D. Nieder, Jana B. Ozolina, Raza Carvalho, Ana M. Vilas-Boas, Vânia Lúcio, M. |
Data: | 28-Set-2016 |
Resumo(s): | Nanocarrier-based chemotherapy is one of the few nanotechnology-based medical therapies that reached the clinics. This happened already in 1995, when the commercial anti cancer drug delivery system DOXIL® was introduced in the market [1]. Albeit these early developments, still today nanotechnology-based drug delivery systems are far from reaching optimal selectivity and controlled release ability. In our study we use different liposomal formulations designed for pH-sensitive drug release and study their biophysical characteristics, when used for trafficking paclitaxel (PTX) and doxorubicin (DOX), both widely used chemotherapeutic anti-cancer drugs. Our work describes a combined spectroscopy and imaging approach to evaluate the biophysical properties of liposomal formulations. We study the nanoscale composition of the nanocarriers using molecular rulers in a fluorescence quenching assay, and analyze the cell uptake characteristics based on the autofluorescence of DOX using confocal microscopy. |
Tipo: | Comunicação em painel |
URI: | https://hdl.handle.net/1822/50323 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDF - FAMO - Comunicações/Communications (with refereeing) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Abstract ICONAN2016.pdf | 17,59 kB | Adobe PDF | Ver/Abrir |