Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/50889
Título: | The α-Arrestin Bul1p Mediates Lactate Transporter Endocytosis in Response to Alkalinization and Distinct Physiological Signals |
Autor(es): | Talaia, Gabriel Gournas, Christos Saliba, Elie Barata-Antunes, Cláudia Casal, Margarida André, Bruno Diallinas, George Paiva, Sandra |
Palavras-chave: | Bul1p Jen1p Endocytosis Lactate transporter α-arrestin |
Data: | 28-Nov-2017 |
Editora: | Elsevier |
Revista: | Journal of Molecular Biology |
Citação: | Talaia G, Gournas C, Saliba E, Barata-Antunes C, Casal M, André B, Diallinas G, Paiva S.The α-Arrestin Bul1p Mediates Lactate Transporter Endocytosis in Response to Alkalinization and Distinct Physiological Signals. J Mol Biol. 2017 Nov 24;429(23):3678-3695. |
Resumo(s): | Eukaryotic α-arrestins connect environmental or stress signaling pathways to the endocytosis of plasma membrane transporters or receptors. The Saccharomyces cerevisiae lactate transporter Jen1p has been used as a model cargo for elucidating the mechanisms underlying endocytic turnover in response to carbon sources. Here, we discover a novel pathway of Jen1p endocytosis mediated by the α-arrestin Bul1p in response to the presence of cycloheximide or rapamycin, or prolonged growth in lactate. While cycloheximide or rapamycin modify cells pleiotropically, the major effect of prolonged growth in lactate was shown to be external pH alkalinization. Importantly, employment of specific inactive Jen1p versions showed that Bul1p-dependent endocytosis requires lactate transport, according to the signal imposed. Our results support a model where conformational changes of Jen1p, associated with substrate/H+ symport, are critical for the efficiency of Bul1p-dependent Jen1p turnover. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/50889 |
DOI: | 10.1016/j.jmb.2017.09.014 |
ISSN: | 0022-2836 |
e-ISSN: | 1089-8638 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0022283617304515 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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article Talaia et al.pdf Acesso restrito! | 2,08 MB | Adobe PDF | Ver/Abrir |