Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/51224
Título: | Signals and mechanisms of endocytosis of eukaryotic lactate transporters |
Autor(es): | Talaia, Gabriel Gournas, Christos Saliba, Elie Antunes, Cláudia Barata Casal, Margarida André, Bruno Diallinas, George Paiva, Sandra |
Data: | Dez-2017 |
Resumo(s): | Eukaryotic cells internalize or recycle their plasma membrane proteins by endocytosis in response to physiological or stress signals imposed by a changing environment. Defects in membrane cargo trafficking lead to protein mislocalization and activation of turnover pathways, which can result into cellular stress and is often related to human diseases. The α-arrestins connect signalling pathways triggered by external stimuli to the endocytosis of specific plasma membrane transporters or receptors. The Saccharomyces cerevisiae lactate transporter Jen1p has been used as a model membrane cargo protein for elucidating aspects of the mechanisms that control the endocytic turnover of specific transporters in response to the presence of glucose. Here, we discover a novel pathway of Jen1p endocytosis and provide further insights on how particular α-arrestins mediate the ubiquitylation of transporters under distinct physiological conditions (presence of cycloheximide or prolonged growth in lactate). |
Tipo: | Poster em conferência |
URI: | https://hdl.handle.net/1822/51224 |
Arbitragem científica: | no |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | DBio - Comunicações/Communications in Congresses |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Posters_MicroBiotec17 Jen1.pdf Acesso restrito! | 1 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons