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https://hdl.handle.net/1822/51538
Título: | Randomized Controlled Trial for Helicobacter pylori Eradication in a Naive Portuguese Population: Is Sequential Treatment Superior to Triple Therapy in Real World Clinical Setting? |
Outro(s) título(s): | Ensaio Clínico Randomizado para o Tratamento do Helicobacter pylori em Doentes Portugueses Naive : É o Tratamento Sequencial Superior ao Tratamento Triplo na Prática Clínica? |
Autor(es): | Carvalho, Pedro Boal Magalhães, Joana Castro, Francisca Dias de Rosa, Bruno Cotter, José Almeida Berkeley |
Palavras-chave: | Anti-Bacterial Agents Drug Therapy Combination Helicobacter Infections/drug therapy Helicobacter pylori Portugal Stomach Neoplasms Farmacoterapia Combinada; Helicobacter pylori; Infecções por Helicobacter/tratamento; Neoplasias do Estôma Farmacoterapia Combinada Infecções por Helicobacter/tratamento Neoplasias do Estôma |
Data: | 2-Jan-2017 |
Editora: | Ordem dos Médicos |
Revista: | Acta Médica Portuguesa |
Citação: | Carvalho, P. B., Magalhães, J., de Castro, F. D., Rosa, B., & Cotter, J. (2017). Randomized Controlled Trial for Helicobacter pylori Eradication in a Naive Portuguese Population: Is Sequential Treatment Superior to Triple Therapy in Real World Clinical Setting?. Acta medica portuguesa, 30(3), 185-189 |
Resumo(s): | Introduction: Helicobacter pylori eradication has become increasingly difficult as resistances to several antibiotics develop. We aimed to compare Helicobacter pylori eradication rates between triple therapy and sequential therapy in a naive Portuguese population. Material and Methods: Prospective randomized trial including consecutive patients referred for first-line Helicobacter pylori eradication treatment. Exclusion criteria: previous gastric surgery/neoplasia, pregnancy/lactancy, allergy to any of the drugs. The compared eradication regimens were triple therapy (pantoprazol, amoxicillin and clarithromycin 12/12 hours, 14 days) and sequential therapy (pantoprazol 12/12 hours for 10 days, amoxicillin 12/12 hours for days 1-5 and clarithromycin plus metronidazol 12/12 hours during days 6 -10). Eradication success was confirmed with urea breath test. Statistical analysis was performed with SPSS v21.0 and a p-value < 0.05 was considered statistically significant. Results: Included 60 patients, 39 (65%) female with mean age 52 years (SD +/- 14.3). Treatment groups were homogeneous for gender, age, indication for treatment and smoking status. No statistical differences were encountered between sequential and triple therapy eradication rates (86.2% vs 77.4%, p = 0.379), global eradication rate was 82%. Tobacco consumption was associated with a significantly lower eradication success (54.5 vs 87.8%, p = 0.022). Discussion: In this randomized controlled trial in a naive Portuguese population, we found a satisfactory global Helicobacter pylori eradication rate of 82%, with no statistical differences observed in the efficacy of the treatment between triple and sequential regimens. Conclusion: These results support the use of either therapy for the first-line eradication of Helicobacter pylori. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/51538 |
DOI: | 10.20344/amp.8072 |
ISSN: | 1646-0758 |
Versão da editora: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8072 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2017 boalcarvalhop_amp.pdf | 326,01 kB | Adobe PDF | Ver/Abrir |