Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/51995| Título: | Exploiting the antiparasitic activity of naphthalimides derivatives |
| Autor(es): | Silva, Anabela Cordeiro da Alves, Maria José Chão Thoo-Lin, Paul Kong Baptista, Catarina Noro, Jennifer Martins Cristo, Gabriela Gaspar, Luís |
| Palavras-chave: | Naphtalimides derivatives anti-parasitic activity cytotoxicity |
| Data: | 2016 |
| Editora: | Pharma Research Library |
| Revista: | International Journal of Chemistry and Pharmaceutical Sciences |
| Resumo(s): | A set of 1,8-naphtalimides derivatives were synthesized and tested against three protozoans that cause important human diseases: Leishmaniainfantum, Trypanosomabrucei and Trypanosomacruzi. Additionally, toxicity was determined by growth inhibition of THP-1 derived macrophages. The results suggest that chemical modifications in the carbon chain linking the naphthalimide and the substituting groups have different effects in the parasites. This work should provide new insights new insights for the design and optimization of more potent and directed naphthalimide derivatives against these organisms. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/51995 |
| ISSN: | 2321-3132 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Gallery Proof IJCPS2793.pdf | 292,77 kB | Adobe PDF | Ver/Abrir |
