Analysis of the effects of propolis extracts on DNA damage

Abstract

Propolis is a natural wax-like resinous product produced by bees from tree buds and exudates and it can be found in beehives. Among the various compounds that make up propolis, flavonoids are some of the more important ones. Flavonoids have been valued by their antigenotoxic effect, which is a direct consequence of their antioxidant properties, as they are reactive oxygen species (ROS) scavengers. ROS are small molecules/free radicals which are associated with various degenerative diseases. Extracts rich in flavonoids have been widely used in the food, drug and cosmetic industries. Although worldwide propolis has already been intensively studied, studies with Portuguese propolis are currently scarce. The aim of this study is to elucidate the influence of Portuguese propolis on DNA damage and recovery. As expected the tested ethanol extracts have DNApreventive activity which correlates with their antioxidant effects shown in the DPPH radical scavenging activity and in reducing power assays.