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https://hdl.handle.net/1822/52197
Título: | Cognitive and emotional impairments in obsessive–compulsive disorder: evidence from functional brain alterations |
Autor(es): | Gonçalves, Óscar F. Carvalho, Sandra Leite, Jorge Fernandes-Gonçalves, Ana Carracedo, Angel Sampaio, Adriana |
Palavras-chave: | Obsessive–compulsive disorder Brain imaging Functional connectivity |
Data: | 2016 |
Editora: | Elsevier España |
Revista: | Porto Biomedical Journal |
Citação: | Gonçalves, O. F., Carvalho, S., Leite, J., Fernandes-Gonçalves, A., Carracedo, A., & Sampaio, A. (2016). Cognitive and Emotional Impairments in Obsessive Compulsive Disorder: Evidence from Functional Brain Alterations. Porto Biomedical Journal, 1, 92-105 |
Resumo(s): | There is a common agreement on the existence of dysfunctional cortico-striatal–thalamus-cortical path-ways in OCD. Despite this consensus, recent studies showed that brain regions other than the CSTC loopsare needed to understand the complexity and diversity of cognitive and emotional deficits in OCD. Thisreview presents examples of research using functional neuroimaging, reporting abnormal brain pro-cesses in OCD that may underlie specific cognitive/executive (inhibitory control, cognitive flexibility,working memory), and emotional impairments (fear/defensive, disgust, guilt, shame). Studies duringresting state conditions show that OCD patients have alterations in connectivity not only within theCSTC pathways but also in more extended resting state networks, particularly the default mode networkand the fronto-parietal network. Additionally, abnormalities in brain functioning have been found inseveral cognitive and emotionally task conditions, namely: inhibitory control (e.g., CSTC loops, fronto-parietal networks, anterior cingulate); cognitive flexibility (e.g., CSTC loops, extended temporal, parietal,and occipital regions); working memory (e.g., CSTC loops, frontal parietal networks, dorsal anterior cin-gulate); fear/defensive (e.g., amygdala, additional brain regions associated with perceptual – parietal,occipital – and higher level cognitive processing – prefrontal, temporal); disgust (e.g., insula); shame(e.g., decrease activity in middle frontal gyrus and increase in frontal, limbic, temporal regions); and guilt(e.g., decrease activity anterior cingulate and increase in frontal, limbic, temporal regions). These find-ings may contribute to the understanding of OCD as both an emotional (i.e., anxiety) and cognitive (i.e.,executive control) disorder. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/52197 |
DOI: | 10.1016/j.pbj.2016.07.005 |
ISSN: | 2444-8664 |
e-ISSN: | 2444-8664 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CIPsi - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Cognitive and Emotional Impairments in Obsessive Compulsive Disorder- Evidence from Functional Brain Alterations.pdf | 566,54 kB | Adobe PDF | Ver/Abrir |