Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/52216
Título: | Alterations of the default mode network connectivity in obsessive-compulsive personality disorder: a pilot study |
Autor(es): | Coutinho, Joana Fernandes Pereira Gonçalves, Óscar F. Soares, José Miguel Montenegro Marques, Paulo César Gonçalves Sampaio, Adriana |
Palavras-chave: | Obsessive-compulsive personality disorder Neuroimaging Functional MRI Default-mode network Functional connectivity |
Data: | 2016 |
Editora: | Elsevier |
Revista: | Psychiatry Research: Neuroimaging |
Resumo(s): | Obsessive-compulsive personality (OCPD) disorder is characterized by a pattern of excessive self-control, perfectionism and behavioral and cognitive rigidity. Despite the fact that OCPD is the most common personality disorder in the general population, published studies looking at the brain correlates of this disorder are practically nonexistent. The main goal of this study was to analyze the presence of brain alterations in OCPD when compared to healthy controls, specifically at the level of the Default Mode Network (DMN). The DMN is a well-established resting state network which was found to be associated with psychological processes that may play a key role in OCPD (e.g., self-awareness, episodic future thinking and mental simulation). Ten individuals diagnosed with OCPD and ten healthy controls underwent a clinical assessment interview and a resting-state functional magnetic resonance imaging (fMRI) acquisition. The results show that OCPD patients presented an increased functional connectivity in the precuneus (i.e., a posterior node of the DMN), known to be involved in the retrieval manipulation of past events in order to solve current problems and develop plans for the future. These results suggest that this key node of the DMN may play an important role in the pathophysiology of OCPD. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/52216 |
DOI: | 10.1016/j.pscychresns.2016.08.007 |
ISSN: | 0925-4927 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals CIPsi - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Alterations of the default mode network connectivity in obsessive-compulsive personality disorder- A pilot study.pdf Acesso restrito! | 595,79 kB | Adobe PDF | Ver/Abrir |