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https://hdl.handle.net/1822/5342
Título: | Cutting edge: IFN-γ regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection |
Autor(es): | Cruz, Andrea Khader, Shabaana A. Torrado, Egídio Fraga, Alexandra G. Pearl, John E. Pedrosa, Jorge Cooper, Andrea M. Castro, António G. |
Palavras-chave: | IFN-alpha IL-17 CD4 T Cells Mycobacterial Infection |
Data: | 2006 |
Editora: | American Association of Immunologists |
Revista: | The Journal of Immunology |
Citação: | "The Journal of Immunology". ISSN 0022-1767. 177 (2006) 1416-1420. |
Resumo(s): | T cell responses are important to the control of infection but are deleterious if not regulated. IFN-γ-deficient mice infected with mycobacteria exhibit enhanced accumulation of activated effector T cells and neutrophils within granulomatous lesions. These cells do not control bacterial growth and compromise the integrity of the infected tissue. We show that IFN-γ-deficient mice have increased numbers of IL-17-producing T cells following infection with Mycobacterium bovis bacille Calmette Gue´rin. Furthermore, exogenous IFN-γ increases IL-12 and decreases IL-23 production by bacille Calmette Gue´rin-infected bone marrow-derived dendritic cells and reduces the frequency of IL-17-producing T cells induced by these bone marrow-derived dendritic cells. These data support the hypothesis that, during mycobacterial infection, both IFN-γ- and IL-17-producing T cells are induced, but that IFN-γ serves to limit the IL-17-producing T cell population. This counterregulation pathway may be an important factor in limiting mycobacterially associated immune- mediated pathology. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/5342 |
ISSN: | 022-1767 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Cruz A et al 2006.pdf | 255,12 kB | Adobe PDF | Ver/Abrir |