Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/55331

TítuloAdvances in nutraceutical delivery systems: From formulation design for bioavailability enhancement to efficacy and safety evaluation
Autor(es)Gonçalves, Raquel F. S.
Martins, Joana T.
Duarte, C. M. M.
Vicente, A. A.
Pinheiro, Ana Cristina
Palavras-chaveNano-delivery systems
Food bioactive compounds
Gastrointestinal fate evaluation
Bioaccessibility
Toxicity
DataAgo-2018
EditoraElsevier
RevistaTrends in Food Science & Technology
CitaçãoGonçalves, Raquel F. S.; Martins, Joana T.; Duarte, C. M. M.; Vicente, António A.; Pinheiro, Ana Cristina, Advances in nutraceutical delivery systems: From formulation design for bioavailability enhancement to efficacy and safety evaluation. Trends in Food Science & Technology, 78, 270-291, 2018
Resumo(s)Background: Aiming at the enhancement of food products' nutritional and health value, the incorporation of nutraceuticals has attracted increasing interest in the last years. However, they often exhibit low water solubility and stability, limiting their direct incorporation into food products. Also, they show very low bioavailability due to limited bioaccessibility, poor absorption and/or chemical transformation within the gastrointestinal tract. This renders their health benefits extremely difficult to be realized by the consumers. Scope and Approach In the present review the recent innovations regarding the formulation and design of bio-based micro and nano-delivery systems to encapsulate nutraceuticals is discussed; it also gives an overview of the challenges associated to their development; and highlights some strategies to enhance nutraceuticals' bioavailability. An insight about delivery systems' potential toxicity (in particular at nano-scale) is also provided. Key Findings and Conclusions Recent developments in the design of bio-based delivery systems offer the possibility of stabilizing and enhancing nutraceuticals' functionality within food products. In fact, different strategies can be used to enhance nutraceuticals' bioavailability: i) nano-delivery systems, besides showing a huge potential for the protection of valuable nutraceuticals during food processing/digestion, can be used to increase their bioavailability; ii) absorption enhancement technologies have been successfully used to increase nutraceuticals' membrane permeation; and iii) excipient foods have been shown to improve nutraceuticals' biological activity. However, the application of these enabling technologies to food is hindered by very pertinent issues that can be summarized in the effective preservation/maximization of the nutraceuticals' bioactivity and safety, once inside the human body.
TipoArtigo
URIhttps://hdl.handle.net/1822/55331
DOI10.1016/j.tifs.2018.06.011
ISSN0924-2244
Versão da editorahttp://www.journals.elsevier.com/trends-in-food-science-and-technology/
Arbitragem científicayes
AcessoAcesso aberto
Aparece nas coleções:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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