Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/55611
Título: | TDF/FTC electrospun nanofibers for topical prevention of HIV transmission |
Autor(es): | Bogas, Sarah Faria, Maria João Lúcio, M. Sarmento, Bruno Neves, José das Viseu, T. M. R. |
Palavras-chave: | Human immunodeficiency virus (HIV) Pre-exposure prophylaxis (PrEP) Electrospun polymeric nanofibers Controlled drug release |
Data: | 2018 |
Editora: | Mary Ann Liebert |
Revista: | AIDS Research and Human Retroviruses |
Resumo(s): | Human immunodeficiency virus (HIV) is still a problem for global health so, there is a strong need to develop effective microbicides that can be used safely to protect from infection during sexual intercourse. This pre-exposure prophylaxis (PrEP) may be formulations containing oral or topical microbicides. Topical formulations have advantages as they are suitable for vaginal or rectal application and allow a higher local concentration of drug. It is recognized that the use of electrospun nanofibers for drug carriers is very promising in the biomedical field. So, the objective of this study is to develop a novel device for local application of antiretroviral microbicides enabling a controlled release of tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC), based on electrospun polymeric nanofibers. The aim of this study is to encapsulate TDF and FTC into electrospun polymeric nanofibers. Chosen polymers were polycaprolactone (PCL) and poly(vinyl alcohol) (PVA). |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/55611 |
ISSN: | 0889-2229 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDF - FAMO - Outros Documentos/Other Documents (without refereeing) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Abstract-HIVR4P-Sarah Bogas-Final.pdf | 286,59 kB | Adobe PDF | Ver/Abrir |