Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/57950
Título: | Nucleus accumbens microcircuit underlying D2-MSN-Driven increase in motivation |
Autor(es): | Cunha, Carina Isabel Soares Coimbra, Bárbara Guimarães Salazar Domingues, Ana Verónica Vasconcelos, Nivaldo António Portela Sousa, Nuno Rodrigues, Ana João |
Palavras-chave: | basal ganglia medium spiny neurons motivation nucleus accumbens optogenetics reward |
Data: | 2018 |
Editora: | Society for Neuroscience |
Revista: | Eneuro |
Citação: | Soares-Cunha, C., Coimbra, B., Domingues, A. V., Vasconcelos, N., Sousa, N., & Rodrigues, A. J. (2018). Nucleus Accumbens Microcircuit Underlying D2-MSN-Driven Increase in Motivation. eNeuro, ENEURO-0386 |
Resumo(s): | The nucleus accumbens (NAc) plays a central role in reinforcement and motivation. Around 95% of the NAc neurons are medium spiny neurons (MSNs), divided into those expressing dopamine receptor D1 (D1R) or dopamine receptor D2 (D2R). Optogenetic activation of D2-MSNs increased motivation, whereas inhibition of these neurons produced the opposite effect. Yet, it is still unclear how activation of D2-MSNs affects other local neurons/interneurons or input terminals and how this contributes for motivation enhancement. To answer this question, in this work we combined optogenetic modulation of D2-MSNs with in loco pharmacological delivery of specific neurotransmitter antagonists in rats. First, we showed that optogenetic activation of D2-MSNs increases motivation in a progressive ratio (PR) task. We demonstrated that this behavioral effect relies on cholinergic-dependent modulation of dopaminergic signalling of ventral tegmental area (VTA) terminals, which requires D1R and D2R signalling in the NAc. D2-MSN optogenetic activation decreased ventral pallidum (VP) activity, reducing the inhibitory tone to VTA, leading to increased dopaminergic activity. Importantly, optogenetic activation of D2-MSN terminals in the VP was sufficient to recapitulate the motivation enhancement. In summary, our data suggests that optogenetic stimulation of NAc D2-MSNs indirectly modulates VTA dopaminergic activity, contributing for increased motivation. Moreover, both types of dopamine receptors signalling in the NAc are required in order to produce the positive behavioral effects. |
Tipo: | Artigo |
Descrição: | Accepted manuscript |
URI: | https://hdl.handle.net/1822/57950 |
DOI: | 10.1523/ENEURO.0386-18.2018 |
ISSN: | 2373-2822 |
e-ISSN: | 2373-2822 |
Versão da editora: | http://www.eneuro.org/content/early/2018/04/19/ENEURO.0386-18.2018 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Soares-Cunha. Nucleus accumbens.pdf | 5,38 MB | Adobe PDF | Ver/Abrir |