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TitleThe impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis
Author(s)Mesquita, Inês Morais
Ferreira, Carolina
Barbosa, Ana Margarida
Ferreira, Catarina Machado
Moreira, Diana
Carvalho, Agostinho
Cunha, Cristina
Rodrigues, Fernando
Dinis-Oliveira, Ricardo Jorge
Estaquier, Jérôme
Castro, António G.
Torrado, Egídio
Silvestre, Ricardo Jorge Leal
KeywordsVisceral leishmaniasis
Multifunctional CD4+ T cells
Issue dateDec-2018
CitationMesquita, I., Ferreira, C., Barbosa, A. M., Ferreira, C. M., et. al. (2018). The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis. Cytokine, 112, 16-20
Abstract(s)Leishmaniasis is a vector-borne disease caused by protozoan parasites from the genus Leishmania. The most severe form of disease is visceral leishmaniasis (VL), which is fatal if left untreated. It has been demonstrated that interleukin (IL)-10, is associated with disease progression and susceptibility. In this work, we took advantage of a transgenic mouse model that expresses high levels of IL-10 upon zinc sulfate administration (pMT-10). We addressed the role of IL-10 during the initial stages of L. donovani infection by analyzing the parasite burden in the spleen and liver of the infected pMT-10 and WT mice as well as the histopathological alterations upon IL-10 induction. Furthermore, the profile of cytokines expressed by T cells was assessed. Our results demonstrate that an increase in IL-10 production has an impact early but not later after infection. This specific temporal role for IL-10-mediated susceptibility to VL is of interest.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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