Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58076
Título: | Immune-evasion strategies of mycobacteria and their implications for the protective immune response |
Autor(es): | Fraga, Alexandra G. Barbosa, Ana Margarida Martins Ferreira, Catarina Machado Fevereiro, João Pedrosa, Jorge Torrado, Egídio |
Palavras-chave: | Adaptive Immunity Animals Cytokines Dendritic Cells Gene Expression Regulation Humans Immunity, Innate Macrophages Mycobacterium Mycobacterium tuberculosis NLR Proteins Phagosomes Signal Transduction T-Lymphocytes Toll-Like Receptors Immune Evasion |
Data: | 2018 |
Editora: | Caister Academic Press |
Revista: | Current Issues in Molecular Biology |
Resumo(s): | Mycobacteria are intracellular pathogens that have macrophages as their main host cells. However, macrophages are also the primary line of defense against invading microorganisms. To survive in the intracellular compartment, virulent mycobacteria have developed several strategies to modulate the activation and the effector functions of macrophages. Despite this, antigen-specific T cells develop during infection. While T cell responses are critical for protection they can also contribute to the success of mycobacteria as human pathogens, as immunopathology associated with these responses facilitates transmission. Here, we provide a brief overview of different immune-evasion strategies of mycobacteria and their impact on the protective immune response. This understanding will further our knowledge in host-pathogen interactions and may provide critical insights for the development of novel host-specific therapies. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58076 |
DOI: | 10.21775/cimb.025.169 |
ISSN: | 1467-3037 |
e-ISSN: | 1467-3045 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Bacterial Evasion 1P Chapter 7.pdf | 740,46 kB | Adobe PDF | Ver/Abrir |