Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58525
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Gomes, Sara Daniela | por |
dc.contributor.author | Oliveira, Claudia Suellen | por |
dc.contributor.author | Azevedo-Silva, João | por |
dc.contributor.author | Casanova, Marta Alexandra Rodrigues | por |
dc.contributor.author | Barreto, Judite | por |
dc.contributor.author | Pereira, Helena | por |
dc.contributor.author | Chaves, Susana | por |
dc.contributor.author | Rodrigues, L. R. | por |
dc.contributor.author | Casal, Margarida | por |
dc.contributor.author | Côrte-Real, Manuela | por |
dc.contributor.author | Baltazar, Fátima | por |
dc.contributor.author | Preto, Ana | por |
dc.date.accessioned | 2019-01-24T11:05:07Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Gomes, S. D., Oliveira, C. S., Azevedo-Silva, J., Casanova, M., Barreto, J., Pereira, H., ... & Baltazar, F. (2020). The Role of Diet Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications. Current medicinal chemistry. | por |
dc.identifier.issn | 0929-8673 | - |
dc.identifier.uri | https://hdl.handle.net/1822/58525 | - |
dc.description.abstract | Colorectal cancer (CRC) is a major cause of cancer-related death worldwide. CRC increased risk has been associated with alterations in the intestinal microbiota, with decreased production of short chain fatty acids (SCFAs). SCFAs produced in the human colon are the major products of bacterial fermentation of undigested dietary fiber and starch. While colonocytes use the three major SCFAs, namely acetate, propionate and butyrate, as energy sources, transformed CRC cells primarily undergo aerobic glycolysis. Compared to normal colonocytes, CRC cells exhibit increased sensitivity to SCFAs, thus indicating they play an important role in cell homeostasis. Manipulation of SCFA levels in the intestine, through changes in microbiota, has therefore emerged as a potential preventive/therapeutic strategy for CRC. Interest in understanding SCFAs mechanism of action in CRC cells has increased in the last years. Several SCFA transporters like SMCT-1, MCT-1 and aquaporins have been identified as the main transmembrane transporters in intestinal cells. Recently, it was shown that acetate promotes plasma membrane re-localization of MCT-1 and triggers changes in the glucose metabolism. SCFAs induce apoptotic cell death in CRC cells, and further mechanisms have been discovered, including the involvement of lysosomal membrane permeabilization, associated with mitochondria dysfunction and degradation. In this review, we will cover the current knowledge on the transport of SCFAs by CRC cells and their effects on CRC metabolism and survival. The impact of increasing SCFA production by manipulation of colon microbiota on the prevention/therapy of CRC will also be addressed. | por |
dc.description.sponsorship | This article is a result of the project EcoAgriFood NORTE-01-0145-FEDER-00009, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF)It counts also with the support of the strategic programme UID/BIA/04050/2013 (POCI-01-0145-FEDER-007569) funded by national funds through the FCT I.P. and by the ERDF through the COMPETE2020 -Programa Operacional Competitividade e Internacionalizacao (POCI).It has also been supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of the UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01- 0145-FEDER-006684). | por |
dc.language.iso | eng | por |
dc.publisher | Bentham Science Publishers | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147337/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147364/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147337/PT | - |
dc.rights | closedAccess | por |
dc.subject | Colorectal cancer | por |
dc.subject | Short chain fatty acids | por |
dc.subject | Microbiota | por |
dc.subject | Cell death mechanism | por |
dc.subject | Metabolism | por |
dc.subject | Cell death | por |
dc.subject | Membrane transport | por |
dc.title | The role of diet related short-chain fatty acids in colorectal cancer metabolism and survival: prevention and therapeutic implications | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.eurekaselect.com/162563/article | por |
oaire.citationStartPage | 4087 | por |
oaire.citationEndPage | 4108 | por |
oaire.citationIssue | 24 | por |
oaire.citationVolume | 27 | por |
dc.identifier.eissn | 1875-533X | - |
dc.identifier.doi | 10.2174/0929867325666180530102050 | por |
dc.identifier.pmid | 29848266 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.description.publicationversion | info:eu-repo/semantics/acceptedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Current Medicinal Chemistry | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series ICVS - Artigos em revistas internacionais / Papers in international journals DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Preto-MS (Corrections) AP14August18.pdf Acesso restrito! | 2,03 MB | Adobe PDF | Ver/Abrir |