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https://hdl.handle.net/1822/58785
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Campo DC | Valor | Idioma |
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dc.contributor.author | Costa, Rui R. | por |
dc.contributor.author | Costa, Diana Pereira Soares | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Pashkuleva, I. | por |
dc.date.accessioned | 2019-01-30T15:22:03Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Costa R. R., Soares da Costa D., Reis R. L., Pashkuleva I. Bioinspired baroplastic glycosaminoglycan sealants for soft tissues, Acta Biomaterialia, pp. in press, doi:10.1016/j.actbio.2019.01.040, 2019 | por |
dc.identifier.issn | 1742-7061 | por |
dc.identifier.uri | https://hdl.handle.net/1822/58785 | - |
dc.description.abstract | We describe biomimetic adhesives inspired by the marine glues fabricated by the sandcastle worm. The formation of stable polyelectrolyte complexes between poly-L-lysine (PLL) and glycosaminoglycans (GAGs) with different sulfation degree â heparin (HEP), chondroitin sulfate (CS) and hyaluronic acid (HA) â is optimized by zeta-potential titrations. These PLL/GAG complexes are transformed into compact polyelectrolyte complexes (coPECs) with controlled water contents and densities via baroplastic processing. Rotational shear tests demonstrate that coPECs containing sulfated GAGs (HEP or CS) have solid-like properties, whereas HA-based complexes form highly hydrated viscous-like networks. The adhesiveness of the generated coPECs (normalized lap shear strength) is tested in dry and wet states using polystyrene and rabbit skin, respectively. In dry state, the adhesives exhibit lap shear strengths in the order of hundreds of kPa, with coPLL/HEP and coPLL/CS being about 1.5 times stronger than coPLL/HA. In wet state, all coPECs seal rabbit skin and recover over 60% of the elongation capacity of intact skin with coPLL/HA providing the sturdiest adhesion (â ¼ 85% elongation recovery). We demonstrate that this is due to the higher water fraction that improves the bonding between the wet specimens, showcasing the potential superior mechanical recovery on injured tissues. | por |
dc.description.sponsorship | The authors acknowledge financial support from "Fundacao para a Ciencia e Tecnologia" (project PTDC/BTM-MAT/28327/2017 and grants SFRH/BPD/95446/2013, SFRH/BPD/85790/2012 and IF/00032/2013), the Portuguese "Programa Operacional Capital Humano" (POCH), the European Social Fund, and the European Commission (H2020 projects NMP-2014-646075 and TWINN-2015-692333). The authors acknowledge Dr. Alain Morais and Dr. Carlos Vilela for supplying the animal skin samples. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.rights | restrictedAccess | por |
dc.subject | Bioadhesives | por |
dc.subject | Biomimetics | por |
dc.subject | Glycosaminoglycans | por |
dc.subject | Polyelectrolyte Complexes | por |
dc.subject | Skin | por |
dc.title | Bioinspired baroplastic glycosaminoglycan sealants for soft tissues | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://reader.elsevier.com/reader/sd/pii/S1742706119300601?token=B0FDCA54B6C9DFB031EB5B38A96DD3BF78F900FBCCC9B30C245AFC3B09377BF8FEC6DC6EF628ABC4FDA8CE7471A0A65C | por |
dc.comments | http://3bs.uminho.pt/node/19720 | por |
oaire.citationStartPage | 108 | por |
oaire.citationEndPage | 117 | por |
oaire.citationVolume | 87 | por |
dc.date.updated | 2019-01-30T09:50:10Z | - |
dc.identifier.doi | 10.1016/j.actbio.2019.01.040 | por |
dc.identifier.pmid | 30665018 | por |
dc.description.publicationversion | info:eu-repo/semantics/acceptedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Acta Biomaterialia | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19720-Costa et al_ActaBio_2019.pdf Acesso restrito! | 1,34 MB | Adobe PDF | Ver/Abrir |