Novel micro-nanofibrous multilayer scaffold for bone tissue engineering applications

Abstract

[Excerpt] Fibrous structures mimicking the natural extracellular matrix (ECM) morphology are considered promising scaffolds for Tissue Engineering (TE). Scaffold architecture determines its structural integrity, mechanical strength, transport properties and the microenvironment for cell adhesion and proliferation. Therefore, several scaffold processing techniques were developed to control the scaffold architecture. Rapid prototyping (RP) allows the production of scaffolds with precise control of porosity and internal pore architecture; while electrospinning (ES) technique has become very popular in the TE community due to the production of submicron ECM-like fiber meshes. [...]